HSF2 Antibody (E-2): sc-377045

HSF2 Antibody (E-2) is a mouse monoclonal IgG3 antibody that detects HSF2 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). HSF2, or heat shock factor 2, plays a crucial role in the cellular response to stress by regulating the expression of heat shock proteins, which are essential for protein folding and protection against cellular damage. HSF2 is primarily located in the nucleus, where HSF2 functions as a transcription factor that binds to heat shock elements in the promoter regions of target genes. The nuclear localization of HSF2 is vital because HSF2 allows for the timely activation of heat shock genes in response to stressors, thereby facilitating the cell′s ability to cope with potentially harmful conditions. Additionally, HSF2 is known to interact with various co-factors and other proteins involved in the stress response, further underscoring HSF2′s importance in maintaining cellular homeostasis. Anti-HSF2 antibody (E-2) is an invaluable tool for researchers studying the mechanisms of stress response and the role of heat shock proteins in health and disease.

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HSF2 Antibody (E-2) References:

1. Transcriptional activation of mouse cytosolic chaperonin CCT subunit genes by heat shock factors HSF1 and HSF2.  |  Kubota, H., et al. 1999. FEBS Lett. 461: 125-9. PMID: 10561509
2. Formation of nuclear stress granules involves HSF2 and coincides with the nucleolar localization of Hsp70.  |  Alastalo, TP., et al. 2003. J Cell Sci. 116: 3557-70. PMID: 12865437
3. Up-regulation of the clusterin gene after proteotoxic stress: implication of HSF1-HSF2 heterocomplexes.  |  Loison, F., et al. 2006. Biochem J. 395: 223-31. PMID: 16336210
4. Isolation of a cDNA for HSF2: evidence for two heat shock factor genes in humans.  |  Schuetz, TJ., et al. 1991. Proc Natl Acad Sci U S A. 88: 6911-5. PMID: 1871106
5. Analysis of the Wnt/B-catenin/TCF4 pathway using SAGE, genome-wide microarray and promoter analysis: Identification of BRI3 and HSF2 as novel targets.  |  Kavak, E., et al. 2010. Cell Signal. 22: 1523-35. PMID: 20538055
6. Regulation of transcription of hypoxia-inducible factor-1α (HIF-1α) by heat shock factors HSF2 and HSF4.  |  Chen, R., et al. 2011. Oncogene. 30: 2570-80. PMID: 21258402
7. CBP-HSF2 structural and functional interplay in Rubinstein-Taybi neurodevelopmental disorder.  |  de Thonel, A., et al. 2022. Nat Commun. 13: 7002. PMID: 36385105
8. Comprehensive analysis of human tissues reveals unique expression and localization patterns of HSF1 and HSF2.  |  Joutsen, J., et al. 2024. Cell Stress Chaperones. 29: 235-271. PMID: 38458311
9. Rapid assay of HSF1 and HSF2 gene expression by RT-PCR.  |  Ding, XZ., et al. 1996. Mol Cell Biochem. 158: 189-92. PMID: 8817481
10. Heat shock response and protein degradation: regulation of HSF2 by the ubiquitin-proteasome pathway.  |  Mathew, A., et al. 1998. Mol Cell Biol. 18: 5091-8. PMID: 9710593

The preferred HSF2 antibody is HSF2 Antibody (G-11): sc-74529.