HSF2 Antibody (3E2): sc-13517
- HSF2 Antibody (3E2) is a rat monoclonal IgG2a, cited in 6 publications, provided at 200 µg/ml
- raised against recombinant full length mouse HSF2
- recommended for detection of HSF2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- TransCruz reagent for Gel Supershift and ChIP applications (sc-13517 X, 200 µg/0.1 ml)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for HSF2 Antibody (3E2). This work is in progress.
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HSF2 Antibody (3E2) is a rat monoclonal IgG2a antibody that detects HSF2 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry (IHC), and enzyme-linked immunosorbent assay (ELISA). HSF2 (3E2) monoclonal antibody plays a crucial role in the regulation of heat shock response, particularly during cellular differentiation and development. HSF2 is primarily located in the nucleus, where HSF2 functions as a transcription factor that binds to heat shock elements in the promoter regions of heat shock genes. Nuclear localization is vital because HSF2 effectively regulates the expression of these genes in response to stress, ensuring that cells can adapt to and survive adverse conditions. HSF2 is known to form trimers for DNA binding, similar to HSF1, which enhances transcriptional activity. HSF2′s ability to respond to various stressors and interaction with other proteins in the heat shock response pathway underscores HSF2′s importance in maintaining cellular homeostasis and protecting against protein misfolding and aggregation.
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HSF2 Antibody (3E2) References:
- Heat shock factor 2 (HSF2) contributes to inducible expression of hsp genes through interplay with HSF1. | Ostling, P., et al. 2007. J Biol Chem. 282: 7077-86. PMID: 17213196
- HSF2 binds to the Hsp90, Hsp27, and c-Fos promoters constitutively and modulates their expression. | Wilkerson, DC., et al. 2007. Cell Stress Chaperones. 12: 283-90. PMID: 17915561
- Heat shock factor 4a (HSF4a) represses HSF2 expression and HSF2-mediated transcriptional activity. | Kim, SA., et al. 2012. J Cell Physiol. 227: 1-6. PMID: 21792930
- Expression of HSF2 decreases in mitosis to enable stress-inducible transcription and cell survival. | Elsing, AN., et al. 2014. J Cell Biol. 206: 735-49. PMID: 25202032
- Structures of HSF2 reveal mechanisms for differential regulation of human heat-shock factors. | Jaeger, AM., et al. 2016. Nat Struct Mol Biol. 23: 147-54. PMID: 26727490
- miR-202 Promotes Cell Apoptosis in Esophageal Squamous Cell Carcinoma by Targeting HSF2. | Meng, X., et al. 2017. Oncol Res. 25: 215-223. PMID: 28277193
- Inhibition of HSF2 SUMOylation via MEL18 upregulates IGF-IIR and leads to hypertension-induced cardiac hypertrophy. | Huang, CY., et al. 2018. Int J Cardiol. 257: 283-290. PMID: 29180262
- CBP-HSF2 structural and functional interplay in Rubinstein-Taybi neurodevelopmental disorder. | de Thonel, A., et al. 2022. Nat Commun. 13: 7002. PMID: 36385105
- Comprehensive analysis of human tissues reveals unique expression and localization patterns of HSF1 and HSF2. | Joutsen, J., et al. 2024. Cell Stress Chaperones. 29: 235-271. PMID: 38458311
- Overexpression of HSF2-beta inhibits hemin-induced heat shock gene expression and erythroid differentiation in K562 cells. | Leppä, S., et al. 1997. J Biol Chem. 272: 15293-8. PMID: 9182556
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HSF2 Antibody (3E2) | sc-13517 | 200 µg/ml | $322.00 | |||
HSTF2 Antibody (3E2) X | sc-13517 X | 200 µg/0.1 ml | $322.00 |