HS3ST3A1 Antibody (E-12): sc-390024

HS3ST3A1 Antibody (E-12) is a mouse monoclonal IgG1 antibody that detects HS3ST3A1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). HS3ST3A1, also known as 3OST3A1 or HS3ST3A, is a 406 amino acid single-pass type II membrane protein primarily localized to the Golgi apparatus, playing a crucial role in heparan sulfate biosynthesis. HS3ST3A1 is expressed ubiquitously, with particularly high levels found in the placenta, heart, kidney, and liver, highlighting its importance in various biological processes. As a heparan sulfate glucosaminyl 3-O-sulfotransferase, HS3ST3A1 specifically transfers a sulfuryl group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate, which is essential for regulating multiple biological activities, including cell signaling, growth factor activity, and extracellular matrix interactions. The gene encoding HS3ST3A1 is located on human chromosome 17, a region comprising over 2.5% of the human genome and encoding more than 1,200 genes, underscoring HS3ST3A1′s significance in human health and disease. Anti-HS3ST3A1 antibody (E-12) serves as an invaluable tool for researchers studying heparan sulfate′s intricate roles in cellular functions and disease mechanisms.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

HS3ST3A1 Antibody (E-12) References:

1. [Primary study on glycan structure in pathopoiesis mechanism of recurrent respiratory papillomatosis].  |  Wang, J., et al. 2008. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 43: 355-9. PMID: 18717311
2. Regulation of CCR5 expression in human placenta: insights from a study of mother-to-child transmission of HIV in Malawi.  |  Joubert, BR., et al. 2010. PLoS One. 5: e9212. PMID: 20169157
3. Establishment of a human lung cancer cell line with high metastatic potential to multiple organs: gene expression associated with metastatic potential in human lung cancer.  |  Nakano, T., et al. 2012. Oncol Rep. 28: 1727-35. PMID: 22922681
4. The heparan sulfate sulfotransferase 3-OST3A (HS3ST3A) is a novel tumor regulator and a prognostic marker in breast cancer.  |  Mao, X., et al. 2016. Oncogene. 35: 5043-55. PMID: 27041583
5. Identification of gene and microRNA changes in response to smoking in human airway epithelium by bioinformatics analyses.  |  Huang, J., et al. 2019. Medicine (Baltimore). 98: e17267. PMID: 31568004
6. Mutational analysis of genes with ureteric progenitor cell-specific expression in branching morphogenesis of the mouse kidney.  |  Rutledge, EA. and McMahon, AP. 2020. Dev Dyn. 249: 765-774. PMID: 32017326
7. ZNF263 is a transcriptional regulator of heparin and heparan sulfate biosynthesis.  |  Weiss, RJ., et al. 2020. Proc Natl Acad Sci U S A. 117: 9311-9317. PMID: 32277030
8. Identification and analysis of microRNA editing events in recurrent bladder cancer based on RNA sequencing: MicroRNA editing level is a potential novel biomarker.  |  Qin, JX., et al. 2022. Front Genet. 13: 984279. PMID: 36199571
9. Identification of potential inhibitors for drug resistance in acute lymphoblastic leukemia through differentially expressed gene analysis and in silico screening.  |  Özay, B., et al. 2024. Anal Biochem. 694: 115619. PMID: 39025197
10. The pathogenic APP N-terminal Val225Ala mutation alters tau protein liquid-liquid phase separation and exacerbates synaptic damage.  |  Chen, J., et al. 2024. Mol Psychiatry.. PMID: 39558004

The preferred HS3ST3A1 antibody is HS3ST3A1 Antibody (D-7): sc-377259.