HS3ST3A1 Antibody (D-7): sc-377259

HS3ST3A1 Antibody (D-7) is a mouse monoclonal IgM antibody that detects HS3ST3A1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-HS3ST3A1 antibody (D-7) is available as a non-conjugated format. HS3ST3A1, also known as heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1, plays a crucial role in heparan sulfate biosynthesis, a polysaccharide vital for various biological processes, including cell signaling, growth factor activity, and cell adhesion. HS3ST3A1 is a 406 amino acid single-pass type II membrane protein primarily localized in the Golgi apparatus, where HS3ST3A1 catalyzes sulfate group transfer to specific glucosamine residues on heparan sulfate chains. Proper functioning of HS3ST3A1 is essential for generating heparan sulfate structures that mediate interactions between cells and their environment, influencing processes such as tissue development and repair. HS3ST3A1 is expressed ubiquitously, with particularly high levels found in the placenta, heart, kidney, and liver, highlighting HS3ST3A1′s importance in various physiological contexts. The gene encoding HS3ST3A1 is located on human chromosome 17, a significant region encoding over 1,200 genes, underscoring the complexity and interconnectivity of biological systems.

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HS3ST3A1 Antibody (D-7) References:

1. A novel role for 3-O-sulfated heparan sulfate in herpes simplex virus 1 entry.  |  Shukla, D., et al. 1999. Cell. 99: 13-22. PMID: 10520990
2. Heparan sulfate D-glucosaminyl 3-O-sulfotransferase-3A sulfates N-unsubstituted glucosamine residues.  |  Liu, J., et al. 1999. J Biol Chem. 274: 38155-62. PMID: 10608887
3. Structural analysis of the sulfotransferase (3-o-sulfotransferase isoform 3) involved in the biosynthesis of an entry receptor for herpes simplex virus 1.  |  Moon, AF., et al. 2004. J Biol Chem. 279: 45185-93. PMID: 15304505
4. Genetic variations in genes involved in heparan sulphate biosynthesis are associated with Plasmodium falciparum parasitaemia: a familial study in Burkina Faso.  |  Atkinson, A., et al. 2012. Malar J. 11: 108. PMID: 22475533
5. Placental expression of heparan sulfate 3-O-sulfotransferase-3A1 in normotensive and pre-eclamptic pregnancies.  |  Amraoui, F., et al. 2015. Placenta. 36: 1218-24. PMID: 26410339
6. Loss of Hs3st3a1 or Hs3st3b1 enzymes alters heparan sulfate to reduce epithelial morphogenesis and adult salivary gland function.  |  Patel, VN., et al. 2021. Matrix Biol. 103-104: 37-57. PMID: 34653670
7. Proteasome Modulator 9 Gene rs14259 Polymorphism in Patients with Diabetic Polyneuropathy.  |  Şalçini, C., et al. 2021. Noro Psikiyatr Ars. 58: 289-291. PMID: 34924789
8. HS3ST3A1 and CAPN8 Serve as Immune-Related Biomarkers for Predicting the Prognosis in Thyroid Cancer.  |  Chen, ZH., et al. 2022. J Oncol. 2022: 6724295. PMID: 36590308
9. Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation.  |  Patel, VN., et al. 2024. Nat Commun. 15: 7584. PMID: 39217171
10. Biosynthesis of heparin/heparan sulfate. The D-glucosaminyl 3-O-sulfotransferase reaction: target and inhibitor saccharides.  |  Razi, N. and Lindahl, U. 1995. J Biol Chem. 270: 11267-75. PMID: 7744762
11. Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Isolation, characterization, and expression of human cdnas and identification of distinct genomic loci.  |  Shworak, NW., et al. 1999. J Biol Chem. 274: 5170-84. PMID: 9988767
12. Expression of heparan sulfate D-glucosaminyl 3-O-sulfotransferase isoforms reveals novel substrate specificities.  |  Liu, J., et al. 1999. J Biol Chem. 274: 5185-92. PMID: 9988768

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-HS3ST3A1 Antibody (D-7) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-HS3ST3A1 Antibody (D-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

HS3ST3A1 Antibody (D-7) Specifications

Alternate Product Name: HS3ST3A1

Product Clone Name: D-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 117-149

Epitope Target: HS3ST3A1

Epitope Species: human

Product Reactivity/Detection: HS3ST3A1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for HS3ST3A1 Antibody (D-7): P: Blocking Peptide