HS2ST1 Antibody (G-10): sc-376530
- HS2ST1 Antibody (G-10) is a mouse monoclonal IgG1 κ HS2ST1 antibody, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 1-170 mapping at the N-terminus of HS2ST1 of human origin
- HS2ST1 Antibody (G-10) is recommended for detection of HS2ST1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine and bovine
- Anti-HS2ST1 Antibody (G-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for HS2ST1 Antibody (G-10) for WB applications. These reagents are now offered in bundles with HS2ST1 Antibody (G-10) (see ordering information below).
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HS2ST1 Antibody (G-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects HS2ST1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). HS2ST1 (G-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. HS2ST1, also known as heparan sulfate 2-O-sulfotransferase 1, is a 356 amino acid single-pass type II membrane protein primarily localized in the Golgi apparatus and belongs to the sulfotransferase 3 family. HS2ST1 plays a critical role in heparan sulfate biosynthesis, a polysaccharide essential for various biological activities, including cell signaling and ligand binding. HS2ST1 catalyzes sulfate group transfer to hexuronic acid residues in maturing heparan sulfate, a modification vital for proper heparan sulfate function in mediating interactions between cells and their environment. Additionally, HS2ST1 undergoes post-translational N-glycosylation, which can influence stability and activity, and may play a role in kidney development. HS2ST1′s ability to regulate heparan sulfate structure and function underscores its importance in developmental processes and disease mechanisms, making anti-HS2ST1 antibody (G-10) a valuable research tool for studying these pathways.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
HS2ST1 Antibody (G-10) References:
- Expression of heparan sulphate L-iduronyl 2-O-sulphotransferase in human kidney 293 cells results in increased D-glucuronyl 2-O-sulphation. | Rong, J., et al. 2000. Biochem J. 346 Pt 2: 463-8. PMID: 10677367
- Essential roles of carbohydrate signals in development, immune response and tissue functions, as revealed by gene targeting. | Muramatsu, T. 2000. J Biochem. 127: 171-6. PMID: 10731680
- Heparan sulfate 2-O-sulfotransferase (Hs2st) and mouse development. | Wilson, VA., et al. 2002. Glycoconj J. 19: 347-54. PMID: 12975615
- Occurrence of sulfated galactans in marine angiosperms: evolutionary implications. | Aquino, RS., et al. 2005. Glycobiology. 15: 11-20. PMID: 15317737
- Mutational study of heparan sulfate 2-O-sulfotransferase and chondroitin sulfate 2-O-sulfotransferase. | Xu, D., et al. 2007. J Biol Chem. 282: 8356-67. PMID: 17227754
- Biosynthesis of heparin/heparan sulfate. The D-glucosaminyl 3-O-sulfotransferase reaction: target and inhibitor saccharides. | Razi, N. and Lindahl, U. 1995. J Biol Chem. 270: 11267-75. PMID: 7744762
- Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. | Seki, N., et al. 1997. DNA Res. 4: 345-9. PMID: 9455484
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HS2ST1 Antibody (G-10) | sc-376530 | 200 µg/ml | $322.00 | |||
HS2ST1 Antibody (G-10): m-IgG Fc BP-HRP Bundle | sc-529897 | 200 µg Ab; 10 µg BP | $361.00 | |||
HS2ST1 Antibody (G-10): m-IgGκ BP-HRP Bundle | sc-522993 | 200 µg Ab, 40 µg BP | $361.00 | |||
HS2ST1 Antibody (G-10): m-IgG1 BP-HRP Bundle | sc-543754 | 200 µg Ab; 20 µg BP | $361.00 | |||
HS2ST1 Antibody (G-10) AC | sc-376530 AC | 500 µg/ml, 25% agarose | $424.00 | |||
HS2ST1 Antibody (G-10) HRP | sc-376530 HRP | 200 µg/ml | $322.00 | |||
HS2ST1 Antibody (G-10) FITC | sc-376530 FITC | 200 µg/ml | $336.00 | |||
HS2ST1 Antibody (G-10) PE | sc-376530 PE | 200 µg/ml | $349.00 | |||
HS2ST1 Antibody (G-10) Alexa Fluor® 488 | sc-376530 AF488 | 200 µg/ml | $364.00 | |||
HS2ST1 Antibody (G-10) Alexa Fluor® 546 | sc-376530 AF546 | 200 µg/ml | $364.00 | |||
HS2ST1 Antibody (G-10) Alexa Fluor® 594 | sc-376530 AF594 | 200 µg/ml | $364.00 | |||
HS2ST1 Antibody (G-10) Alexa Fluor® 647 | sc-376530 AF647 | 200 µg/ml | $364.00 | |||
HS2ST1 Antibody (G-10) Alexa Fluor® 680 | sc-376530 AF680 | 200 µg/ml | $364.00 | |||
HS2ST1 Antibody (G-10) Alexa Fluor® 790 | sc-376530 AF790 | 200 µg/ml | $364.00 |