HPV16 L2 Antibody (2JGmab#8): sc-65710
- HPV16 L2 Antibody (2JGmab#8) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 1-40 of HPV16 L2
- recommended for detection of HPV-16 by WB, IP and IF
- See HPV16 L2 (2JGmab#5): sc-65709 for HPV16 L2 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for HPV16 L2 Antibody (2JGmab#8). This work is in progress.
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HPV16 L2 Antibody (2JGmab#8) is a mouse monoclonal IgG1 antibody that detects HPV16 L2 specifically in HPV-16 by applications such as western blotting (WB) and immunofluorescence (IF). HPV16 L2 plays a crucial role in the life cycle of the human papillomavirus, particularly in the assembly and encapsidation of the viral genome. HPV16 L2 is located in the nucleus, where HPV16 L2 interacts with the major capsid protein L1, facilitating the initial steps of viral infection. The C-terminal region of HPV16 L2 is essential for binding to L1, which is necessary for the efficient encapsidation of the viral DNA. This interaction ensures the proper assembly of the viral capsid, allowing viral infection of host cells. Additionally, HPV16 L2′s localization to punctate nuclear regions known as promonocytic leukemia protein oncogenic domains (PODs) highlights HPV16 L2′s importance in the viral life cycle and potential oncogenic processes. Anti-HPV16 L2 antibody (2JGmab#8) is an invaluable tool for researchers studying the mechanisms of HPV infection and the role of HPV16 L2 in viral pathogenesis.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
HPV16 L2 Antibody (2JGmab#8) References:
- Cleavage of the papillomavirus minor capsid protein, L2, at a furin consensus site is necessary for infection. | Richards, RM., et al. 2006. Proc Natl Acad Sci U S A. 103: 1522-7. PMID: 16432208
- Identification of a dynein interacting domain in the papillomavirus minor capsid protein l2. | Florin, L., et al. 2006. J Virol. 80: 6691-6. PMID: 16775357
- Expression pattern and subcellular localization of human papillomavirus minor capsid protein L2. | Lin, Z., et al. 2009. Am J Pathol. 174: 136-43. PMID: 19095951
- Natural variants in the major neutralizing epitope of human papillomavirus minor capsid protein L2. | Seitz, H., et al. 2013. Int J Cancer. 132: E139-48. PMID: 22961598
- Differential expression of HPV16 L2 gene in cervical cancers harboring episomal HPV16 genomes: influence of synonymous and non-coding region variations. | Mandal, P., et al. 2013. PLoS One. 8: e65647. PMID: 23762404
- Seroepidemiology of Human Papillomavirus 16 (HPV16) L2 and Generation of L2-Specific Human Chimeric Monoclonal Antibodies. | Wang, JW., et al. 2015. Clin Vaccine Immunol. 22: 806-16. PMID: 25972404
- HPV16 L2 improves HPV16 L1 gene delivery as an important approach for vaccine design against cervical cancer. | Namvar, A., et al. 2016. Bratisl Lek Listy. 117: 179-84. PMID: 26925750
- Conformational and linear epitopes on virus-like particles of human papillomavirus type 33 identified by monoclonal antibodies to the minor capsid protein L2. | Volpers, C., et al. 1995. J Gen Virol. 76 (Pt 11): 2661-7. PMID: 7595373
- The papillomavirus minor capsid protein, L2, induces localization of the major capsid protein, L1, and the viral transcription/replication protein, E2, to PML oncogenic domains. | Day, PM., et al. 1998. J Virol. 72: 142-50. PMID: 9420209
- A surface immunodeterminant of human papillomavirus type 16 minor capsid protein L2. | Kawana, K., et al. 1998. Virology. 245: 353-9. PMID: 9636375
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HPV16 L2 Antibody (2JGmab#8) | sc-65710 | 200 µg/ml | $316.00 |