HPV16 L1 Antibody (MD2H11): sc-65713
- HPV16 L1 Antibody (MD2H11) is a mouse monoclonal IgG1 κ, cited in 5 publications, provided at 200 µg/ml
- raised against HPV16 L1
- HPV16 L1 Antibody (MD2H11) is recommended for detection of HPV-16 by WB and IF; may cross-react with HPV11 L1 and HPV18 L2
- Anti-HPV16 L1 Antibody (MD2H11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for HPV16 L1 Antibody (MD2H11) for WB applications. These reagents are now offered in bundles with HPV16 L1 Antibody (MD2H11) (see ordering information below).
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SEE ALSO...
HPV16 L1 Antibody (MD2H11) is a mouse monoclonal IgG1 kappa light chain antibody that detects HPV16 L1 protein of HPV-16 origin by western blotting (WB) and immunofluorescence (IF). Anti-HPV16 L1 antibody (MD2H11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. HPV16 L1 forms the major structural component of the viral capsid, essential for infecting host cells. Pentameric assembly of HPV16 L1 creates a stable and protective shell around the viral genome, allowing viral evasion of host immune response during initial infection. The C-terminus of HPV16 L1 enables DNA binding and packaging while facilitating interaction with minor capsid protein L2, necessary for efficient viral genome encapsidation. Expression of HPV16 L1 remains restricted to upper layers of infected epithelium, highlighting a role in later stages of viral life cycle. HPV16 L1 (MD2H11) monoclonal antibody enables researchers to investigate HPV16 infection mechanisms and develop therapeutic strategies targeting this pathogen.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
HPV16 L1 Antibody (MD2H11) References:
- Mucosal vaccination with a recombinant Salmonella typhimurium expressing human papillomavirus type 16 (HPV16) L1 virus-like particles (VLPs) or HPV16 VLPs purified from insect cells inhibits the growth of HPV16-expressing tumor cells in mice. | Revaz, V., et al. 2001. Virology. 279: 354-60. PMID: 11145916
- Nuclear import strategies of high risk HPV16 L1 major capsid protein. | Nelson, LM., et al. 2002. J Biol Chem. 277: 23958-64. PMID: 11971900
- Characterization of HPV16 L1 loop domains in the formation of a type-specific, conformational epitope. | Olcese, VA., et al. 2004. BMC Microbiol. 4: 29. PMID: 15260888
- HPV16 L1 capsid protein expressed from viable adenovirus recombinants elicits neutralizing antibody in mice. | Berg, M., et al. 2007. Vaccine. 25: 3501-10. PMID: 16914239
- Transgenic tobacco expressed HPV16-L1 and LT-B combined immunization induces strong mucosal and systemic immune responses in mice. | Hongli, L., et al. 2013. Hum Vaccin Immunother. 9: 83-9. PMID: 23108357
- HPV16 L1 and L2 DNA methylation predicts high-grade cervical intraepithelial neoplasia in women with mildly abnormal cervical cytology. | Lorincz, AT., et al. 2013. Int J Cancer. 133: 637-44. PMID: 23335178
- One-prime multi-boost strategy immunization with recombinant DNA, adenovirus, and MVA vector vaccines expressing HPV16 L1 induces potent, sustained, and specific immune response in mice. | Li, LL., et al. 2016. Antiviral Res. 128: 20-7. PMID: 26821205
- A Live Vector Expressing HPV16 L1 Generates an Adjuvant-Induced Antibody Response In-vivo. | Shirbaghaee, Z., et al. 2015. Iran J Cancer Prev. 8: e3991. PMID: 26855722
- Using the omega leader sequence of tobacco mosaic virus to transform tomato fruits with the papillomavirus hpv16 L1 gene to enhance production of the antigenic protein HPV16 L11. | Salyaev, RK., et al. 2016. Dokl Biochem Biophys. 468: 187-9. PMID: 27417716
- Effect of HPV16 L1 virus-like particles on the aggregation of non-functionalized gold nanoparticles. | Palomino-Vizcaino, G., et al. 2018. Biosens Bioelectron. 100: 176-183. PMID: 28889068
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HPV16 L1 Antibody (MD2H11) | sc-65713 | 200 µg/ml | $316.00 | |||
HPV16 L1 Antibody (MD2H11): m-IgG Fc BP-HRP Bundle | sc-526962 | 200 µg Ab; 10 µg BP | $354.00 | |||
HPV16 L1 Antibody (MD2H11): m-IgG1 BP-HRP Bundle | sc-532335 | 200 µg Ab; 20 µg BP | $354.00 | |||
HPV16 L1 Antibody (MD2H11) AC | sc-65713 AC | 500 µg/ml, 25% agarose | $416.00 | |||
HPV16 L1 Antibody (MD2H11) HRP | sc-65713 HRP | 200 µg/ml | $316.00 | |||
HPV16 L1 Antibody (MD2H11) FITC | sc-65713 FITC | 200 µg/ml | $330.00 | |||
HPV16 L1 Antibody (MD2H11) PE | sc-65713 PE | 200 µg/ml | $343.00 | |||
HPV16 L1 Antibody (MD2H11) Alexa Fluor® 488 | sc-65713 AF488 | 200 µg/ml | $357.00 | |||
HPV16 L1 Antibody (MD2H11) Alexa Fluor® 546 | sc-65713 AF546 | 200 µg/ml | $357.00 | |||
HPV16 L1 Antibody (MD2H11) Alexa Fluor® 594 | sc-65713 AF594 | 200 µg/ml | $357.00 | |||
HPV16 L1 Antibody (MD2H11) Alexa Fluor® 647 | sc-65713 AF647 | 200 µg/ml | $357.00 | |||
HPV16 L1 Antibody (MD2H11) Alexa Fluor® 680 | sc-65713 AF680 | 200 µg/ml | $357.00 | |||
HPV16 L1 Antibody (MD2H11) Alexa Fluor® 790 | sc-65713 AF790 | 200 µg/ml | $357.00 |