HPV16 E2 Antibody (TVG 261): sc-53326
- HPV16 E2 Antibody (TVG 261) is a mouse monoclonal IgG1 κ, cited in 4 publications, provided at 200 µg/ml
- raised against Vaccinia-E2 followed by intravenous injection of the maltose binding protein MBP-E2
- recommended for detection of HPV-16 E2 by WB
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for HPV16 E2 Antibody (TVG 261) for WB applications. These reagents are now offered in bundles with HPV16 E2 Antibody (TVG 261) (see ordering information below).
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HPV16 E2 Antibody (TVG 261) is a mouse monoclonal IgG1 antibody that detects HPV-16 E2 in human samples by western blotting (WB). HPV-16 E2 plays a crucial role in viral DNA replication regulation and maintains infected cell homeostasis. HPV-16 E2 is primarily located in the nucleus, where HPV-16 E2 interacts with viral genome and host cellular factors to modulate gene expression. Nuclear localization of HPV-16 E2 enables regulation of E6 and E7 oncoprotein expression, which are critical for cervical cancer progression. Through binding to specific sites within viral long control region, HPV-16 E2 influences transcriptional activity of these oncoproteins, and disruption through HPV genome integration into host DNA can lead to their overexpression, contributing to malignant transformation. HPV-16 E2 induces apoptotic cell death through interactions with p53 and viral genome, highlighting dual roles in viral pathogenesis and potential therapeutic targeting.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HPV16 E2 Antibody (TVG 261) | sc-53326 | 200 µg/ml | $322.00 | |||
HPV16 E2 Antibody (TVG 261): m-IgG Fc BP-HRP Bundle | sc-536934 | 200 µg Ab; 10 µg BP | $361.00 | |||
HPV16 E2 Antibody (TVG 261): m-IgGκ BP-HRP Bundle | sc-534110 | 200 µg Ab; 40 µg BP | $361.00 | |||
HPV16 E2 Antibody (TVG 261): m-IgG1 BP-HRP Bundle | sc-544907 | 200 µg Ab; 20 µg BP | $361.00 |