HPA1 Antibody (4D7): sc-293205
- HPA1 Antibody (4D7) is a mouse monoclonal IgG2b κ, cited in 1 publications, provided at 100 µg/ml
- raised against a partial recombinant protein representing amino acids 72-170 of HPA1 of human origin
- recommended for detection of HPA1 of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for HPA1 Antibody (4D7). This work is in progress.
QUICK LINKS
HPA1 Antibody (4D7) is a mouse monoclonal IgG2b antibody that detects heparanase 1 (HPA1) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). HPA1 plays a crucial role in degrading heparan sulfate side chains of heparan sulfate proteoglycans, which are vital components of the extracellular matrix. This degradation facilitates the extravasation of blood-borne tumor cells and inflammatory leukocytes, contributing to tumor metastasis and inflammation. HPA1 undergoes proteolytic processing at the cell surface, generating an active form that induces angiogenesis and promotes tumor vascularization. HPA1′s ability to release growth factors and cytokines upon degradation stimulates cell proliferation and chemotaxis. Fibroblasts endocytose extracellular HPA1, leading to cytoplasmic accumulation, which may influence cellular signaling and tumor biology. The gene encoding human HPA1 is located on chromosome 4q21.3, highlighting genetic significance in various biological processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
HPA1 Antibody (4D7) References:
- Biochemical characterization of the active heterodimer form of human heparanase (Hpa1) protein expressed in insect cells. | McKenzie, E., et al. 2003. Biochem J. 373: 423-35. PMID: 12713442
- The hpa1 mutant of Arabidopsis reveals a crucial role of histidine homeostasis in root meristem maintenance. | Mo, X., et al. 2006. Plant Physiol. 141: 1425-35. PMID: 16815950
- Mutations in the N-terminal coding region of the harpin protein Hpa1 from Xanthomonas oryzae cause loss of hypersensitive reaction induction in tobacco. | Wang, XY., et al. 2008. Appl Microbiol Biotechnol. 81: 359-69. PMID: 18791711
- Plant growth enhancement and associated physiological responses are coregulated by ethylene and gibberellin in response to harpin protein Hpa1. | Li, X., et al. 2014. Planta. 239: 831-46. PMID: 24395199
- Frequency of human platelet antigens (HPA)-1, -2, -5 and -15 in Brazilian blood donors and establishment of a panel of HPA-typed donors. | Mangerona, CM., et al. 2015. Transfus Med. 25: 189-94. PMID: 26033262
- [Analysis of HPA1-16 and HLA-A, B gene polymorphisms among ethnic Han population from Shandong]. | Zhang, Y., et al. 2016. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 33: 690-3. PMID: 27577225
- Rice aquaporin PIP1;3 and harpin Hpa1 of bacterial blight pathogen cooperate in a type III effector translocation. | Li, P., et al. 2019. J Exp Bot. 70: 3057-3073. PMID: 30921464
- Genetic polymorphism of HPA1-17 alloantigen system in the Achang and Jingpo populations population in Yunnan. | Dong, W., et al. 2020. Ann Palliat Med. 9: 1990-1996. PMID: 32692222
- HPA1-29w Genotyping and the Foundation for the Platelet Apheresis Registry in Jiangsu Province of China by MassARRAY Spectrometry. | Dai, X., et al. 2024. Transfus Med Hemother. 51: 345-350. PMID: 39371254
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HPA1 Antibody (4D7) | sc-293205 | 100 µg/ml | $322.00 |