HoxD1 Antibody (H-6): sc-365853
- HoxD1 Antibody (H-6) is a mouse monoclonal IgG1 κ HoxD1 antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 1-180 mapping at the N-terminus of HoxD1 of human origin
- HoxD1 Antibody (H-6) is recommended for detection of HoxD1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-HoxD1 Antibody (H-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- TransCruz reagent for ChIP application (sc-365853 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for HoxD1 Antibody (H-6) for WB applications. These reagents are now offered in bundles with HoxD1 Antibody (H-6) (see ordering information below).
HoxD1 Antibody (H-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects HoxD1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-HoxD1 antibody (H-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. HoxD1 protein plays a crucial role in regulating gene expression during embryonic development, particularly in anterior-posterior body axis formation. HoxD1 binding to DNA is significantly enhanced through dimerization with PBX homeoproteins, increasing transcriptional activity. This interaction is vital for precise regulation of developmental processes, as HoxD1 is involved in patterning structures such as forelimb and axial skeleton. HoxD1 also interacts with other proteins, including HMG1, which enhances transcriptional activation, while HoxD8 acts as an antagonist, highlighting protein-protein interactions in modulating Hox gene function. Dynamic expression of HoxD1 in presomitic mesoderm and varying levels during diencephalon development underscore a critical role in developmental biology.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
HoxD1 Antibody (H-6) References:
- Coordinated expression of Hoxa2, Hoxd1 and Pax6 in the developing diencephalon. | Wolf, LV., et al. 2001. Neuroreport. 12: 329-33. PMID: 11209945
- Localized and transient transcription of Hox genes suggests a link between patterning and the segmentation clock. | Zákány, J., et al. 2001. Cell. 106: 207-17. PMID: 11511348
- Regulation in vitro of an L-CAM enhancer by homeobox genes HoxD9 and HNF-1. | Goomer, RS., et al. 1994. Proc Natl Acad Sci U S A. 91: 7985-9. PMID: 7914699
- Specificity of HOX protein function depends on DNA-protein and protein-protein interactions, both mediated by the homeo domain. | Zappavigna, V., et al. 1994. Genes Dev. 8: 732-44. PMID: 7926763
- Specific and redundant functions of the paralogous Hoxa-9 and Hoxd-9 genes in forelimb and axial skeleton patterning. | Fromental-Ramain, C., et al. 1996. Development. 122: 461-72. PMID: 8625797
- HMG1 interacts with HOX proteins and enhances their DNA binding and transcriptional activation. | Zappavigna, V., et al. 1996. EMBO J. 15: 4981-91. PMID: 8890171
- Distinct HOX N-terminal arm residues are responsible for specificity of DNA recognition by HOX monomers and HOX.PBX heterodimers. | Phelan, ML. and Featherstone, MS. 1997. J Biol Chem. 272: 8635-43. PMID: 9079695
- Shaping animal body plans in development and evolution by modulation of Hox expression patterns. | Gellon, G. and McGinnis, W. 1998. Bioessays. 20: 116-25. PMID: 9631657
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HoxD1 Antibody (H-6) | sc-365853 | 200 µg/ml | $316.00 | |||
HoxD1 Antibody (H-6): m-IgG Fc BP-HRP Bundle | sc-529492 | 200 µg Ab; 10 µg BP | $354.00 | |||
HoxD1 Antibody (H-6): m-IgGκ BP-HRP Bundle | sc-522395 | 200 µg Ab, 40 µg BP | $354.00 | |||
HoxD1 Antibody (H-6): m-IgG1 BP-HRP Bundle | sc-543542 | 200 µg Ab; 20 µg BP | $354.00 | |||
HoxD1 Antibody (H-6) X | sc-365853 X | 200 µg/0.1 ml | $316.00 | |||
HoxD1 Antibody (H-6) AC | sc-365853 AC | 500 µg/ml, 25% agarose | $416.00 | |||
HoxD1 Antibody (H-6) HRP | sc-365853 HRP | 200 µg/ml | $316.00 | |||
HoxD1 Antibody (H-6) FITC | sc-365853 FITC | 200 µg/ml | $330.00 | |||
HoxD1 Antibody (H-6) PE | sc-365853 PE | 200 µg/ml | $343.00 | |||
HoxD1 Antibody (H-6) Alexa Fluor® 488 | sc-365853 AF488 | 200 µg/ml | $357.00 | |||
HoxD1 Antibody (H-6) Alexa Fluor® 546 | sc-365853 AF546 | 200 µg/ml | $357.00 | |||
HoxD1 Antibody (H-6) Alexa Fluor® 594 | sc-365853 AF594 | 200 µg/ml | $357.00 | |||
HoxD1 Antibody (H-6) Alexa Fluor® 647 | sc-365853 AF647 | 200 µg/ml | $357.00 | |||
HoxD1 Antibody (H-6) Alexa Fluor® 680 | sc-365853 AF680 | 200 µg/ml | $357.00 | |||
HoxD1 Antibody (H-6) Alexa Fluor® 790 | sc-365853 AF790 | 200 µg/ml | $357.00 |