HoxA10 Antibody (F-4): sc-271954

HoxA10 Antibody (F-4) is a mouse monoclonal IgG2b antibody that detects HoxA10 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). HoxA10 plays a crucial role in embryonic development as a transcriptional regulator, particularly in the genitourinary tract and uterus, where HoxA10 expression is tightly regulated by hormonal changes. Notably, HoxA10 is upregulated during the midsecretory phase of the menstrual cycle, coinciding with elevated progesterone levels, which is essential for preparing the endometrium for potential implantation. HoxA10 expression is influenced by progesterone, as demonstrated by a concentration-dependent increase in cultured endometrial cells, and this regulation is disrupted in conditions such as endometriosis, where affected patients fail to show the expected mid-luteal rise in HoxA10 expression. Understanding the dynamics of HoxA10 expression not only sheds light on normal reproductive physiology but also highlights potential implications in reproductive pathologies, making anti-HoxA10 antibody (F-4) a valuable tool for researchers studying these critical biological processes.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

HoxA10 Antibody (F-4) References:

1. HOXA10 expression in endometrial adenocarcinoma.  |  Lane, DB., et al. 2004. Tumour Biol. 25: 264-9. PMID: 15627890
2. HoxA10 activates CDX4 transcription and Cdx4 activates HOXA10 transcription in myeloid cells.  |  Bei, L., et al. 2011. J Biol Chem. 286: 19047-64. PMID: 21471217
3. HoxA10 Terminates Emergency Granulopoiesis by Increasing Expression of Triad1.  |  Wang, H., et al. 2015. J Immunol. 194: 5375-87. PMID: 25895533
4. HOXA10 controls proliferation, migration and invasion in oral squamous cell carcinoma.  |  Carrera, M., et al. 2015. Int J Clin Exp Pathol. 8: 3613-23. PMID: 26097543
5. Epigenetic Dynamics of HOXA10 Gene in Infertile Women With Endometriosis.  |  Samadieh, Y., et al. 2019. Reprod Sci. 26: 88-96. PMID: 29592776
6. HOXA10 deteriorates gastric cancer through activating JAK1/STAT3 signaling pathway.  |  Chen, W., et al. 2019. Cancer Manag Res. 11: 6625-6635. PMID: 31406476
7. LncRNA NEAT1 affects endometrial receptivity by regulating HOXA10 promoter activity.  |  Geng, J., et al. 2022. Cell Cycle. 21: 1932-1944. PMID: 35574918
8. Modular scaffolding by lncRNA HOXA10-AS promotes oral cancer progression.  |  Chen, YT., et al. 2022. Cell Death Dis. 13: 629. PMID: 35858923
9. MEKK4-mediated Phosphorylation of HOXA10 at Threonine 362 facilitates embryo adhesion to the endometrial epithelium.  |  Zhang, M., et al. 2022. Cell Death Discov. 8: 415. PMID: 36216824
10. A Novel HOXA10-Associated 5-Gene-Based Prognostic Signature for Stratification of Short-term Survivors of Pancreatic Ductal Adenocarcinoma.  |  Kisling, SG., et al. 2023. Clin Cancer Res. 29: 3759-3770. PMID: 37432996

The preferred HoxA10 antibody is HoxA10 Antibody (E-11): sc-271428.