HOOK1 Antibody (JA.25): sc-130453
- HOOK1 Antibody (JA.25) is a mouse monoclonal IgG2a κ provided at 100 µg/ml
- raised against recombinant HOOK1 of human origin
- recommended for detection of HOOK1 of human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for HOOK1 Antibody (JA.25). This work is in progress.
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HOOK1 Antibody (JA.25) is a mouse monoclonal IgG2a light chain antibody that detects HOOK1 in human samples through applications such as western blotting (WB) and immunoprecipitation (IP). HOOK1 is a crucial cytoskeletal linker protein that plays a significant role in endocytic membrane trafficking, facilitating the spatial organization of membrane-trafficking systems by interacting with microtubules. HOOK1 exists as a homodimer, a structure likely stabilized by its central coiled-coil domain, which is essential for its function in cellular processes. Notably, HOOK1 is involved in spermatid differentiation, where HOOK1 aids in the positioning of manchette microtubules and the flagellum, highlighting its importance in male fertility. Unlike HOOK3, which is associated with the organization of the cis-Golgi compartment, HOOK1 primarily localizes to the cytoplasm and does not interact with the Golgi complex, underscoring its specialized role in cellular dynamics. HOOK1 (JA.25) antibody is an invaluable tool for researchers studying the intricate mechanisms of cellular trafficking and spermatogenesis.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HOOK1 Antibody (JA.25) | sc-130453 | 100 µg/ml | $333.00 |