Homer-3 Antibody (E-6): sc-376155

Homer-3 Antibody (E-6) is a mouse monoclonal IgM antibody that detects Homer-3 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Homer-3 is a crucial member of the Homer family of proteins, which are immediate early gene products that play a significant role in synaptic signaling by binding to group 1 metabotropic glutamate receptors (mGluRs). These receptors are essential for triggering intracellular calcium release, a process vital for various neuronal functions, including synaptic plasticity and memory formation. Unlike Homer-1a, which is transiently expressed and does not multimerize, Homer-3 is constitutively expressed and features a coiled-coil domain that facilitates self-multimerization, thereby enhancing Homer-3′s ability to form complexes with mGluRs and other signaling proteins. This multimerization is important as Homer-3 effectively links mGluRs with inositol triphosphate receptors (IP3R), thereby influencing calcium signaling pathways that are critical for neuronal communication and plasticity. Homer-3 (E-6) antibody is an invaluable tool for researchers studying the intricate mechanisms of synaptic transmission and the role of Homer proteins in neurobiology.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Homer-3 Antibody (E-6) References:

1. Growth and differentiation effects of Homer3 on a leukemia cell line.  |  Li, Z., et al. 2013. Asian Pac J Cancer Prev. 14: 2525-8. PMID: 23725168
2. Calcium regulates the interaction of amyloid precursor protein with Homer3 protein.  |  Kyratzi, E. and Efthimiopoulos, S. 2014. Neurobiol Aging. 35: 2053-63. PMID: 24792907
3. Homer2 and Homer3 modulate RANKL-induced NFATc1 signaling in osteoclastogenesis and bone metabolism.  |  Son, A., et al. 2019. J Endocrinol. 242: 241-249. PMID: 31319381
4. HOMER3 facilitates growth factor-mediated β-Catenin tyrosine phosphorylation and activation to promote metastasis in triple negative breast cancer.  |  Liu, Q., et al. 2021. J Hematol Oncol. 14: 6. PMID: 33407765
5. Homer2 and Homer3 Act as Novel Biomarkers in Diagnosis of hepatitis B virus-induced Hepatocellular Carcinoma.  |  Luo, P., et al. 2021. J Cancer. 12: 3439-3447. PMID: 33995622
6. Long non-coding RNA HOMER3-AS1 drives hepatocellular carcinoma progression via modulating the behaviors of both tumor cells and macrophages.  |  Pu, J., et al. 2021. Cell Death Dis. 12: 1103. PMID: 34815380
7. Cerebellar Swelling Followed by Atrophy in Anti-Homer-3 Antibody-Associated Cerebellitis.  |  Hu, Y. and Sun, Q. 2022. Neurology. 99: 610-611. PMID: 35858816
8. HOMER3 promotes non-small cell lung cancer growth and metastasis primarily through GABPB1-mediated mitochondrial metabolism.  |  Sun, T., et al. 2023. Cell Death Dis. 14: 814. PMID: 38081871
9. HOMER3 promotes liver hepatocellular carcinoma cancer progression by -upregulating EZH2 and mediating miR-361/GPNMB axis.  |  Chen, L., et al. 2024. Pathol Res Pract. 254: 155150. PMID: 38266459
10. Identification of homer protein homolog 3 as a prognostic marker of colon adenocarcinoma.  |  Luo, M., et al. 2024. Heliyon. 10: e33344. PMID: 39035486

The preferred Homer antibody is Homer Antibody (D-3): sc-17842.