Homer-3 Antibody (D-8): sc-271764

Homer-3 Antibody (D-8) is a mouse monoclonal IgG2b antibody that detects Homer-3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Homer-3 is a member of the Homer family of proteins, which are crucial for synaptic signaling and plasticity, particularly in the context of group 1 metabotropic glutamate receptors (mGluRs). These receptors play a significant role in mediating excitatory neurotransmission and are involved in various neurological processes, including learning and memory. The structure of Homer-3 includes a coiled-coil domain that facilitates self-multimerization, allowing Homer-3 to form complexes that effectively link mGluRs to intracellular signaling pathways, such as those involving inositol triphosphate receptors. This structural feature is essential for Homer-3′s function, as Homer-3 enables the formation of signaling scaffolds that are vital for the proper transmission of synaptic signals. Anti-Homer-3 antibody (D-8) helps researchers explore the dynamics of synaptic signaling and Homer-3′s role in various physiological and pathological conditions, enhancing our understanding of synaptic plasticity and its implications in neurodegenerative diseases.

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Homer-3 Antibody (D-8) References:

1. Cutting edge: association with I kappa B kinase beta regulates the subcellular localization of Homer3.  |  Yatherajam, G., et al. 2010. J Immunol. 185: 2665-9. PMID: 20693425
2. Calcium regulates the interaction of amyloid precursor protein with Homer3 protein.  |  Kyratzi, E. and Efthimiopoulos, S. 2014. Neurobiol Aging. 35: 2053-63. PMID: 24792907
3. Homer2 and Homer3 modulate RANKL-induced NFATc1 signaling in osteoclastogenesis and bone metabolism.  |  Son, A., et al. 2019. J Endocrinol. 242: 241-249. PMID: 31319381
4. HOMER3 facilitates growth factor-mediated β-Catenin tyrosine phosphorylation and activation to promote metastasis in triple negative breast cancer.  |  Liu, Q., et al. 2021. J Hematol Oncol. 14: 6. PMID: 33407765
5. Homer2 and Homer3 Act as Novel Biomarkers in Diagnosis of hepatitis B virus-induced Hepatocellular Carcinoma.  |  Luo, P., et al. 2021. J Cancer. 12: 3439-3447. PMID: 33995622
6. Long non-coding RNA HOMER3-AS1 drives hepatocellular carcinoma progression via modulating the behaviors of both tumor cells and macrophages.  |  Pu, J., et al. 2021. Cell Death Dis. 12: 1103. PMID: 34815380
7. Acute Cerebellitis Associated With Anti-homer 3 Antibodies: A Rare Case Report and Literature Review.  |  Miao, A., et al. 2022. Front Neurol. 13: 837937. PMID: 35250837
8. Anti-homer-3 Antibody Encephalitis in a 10-Year-Old Child: Case Report and Review of the Literature.  |  Kuang, Z., et al. 2022. Front Neurol. 13: 929778. PMID: 35769364
9. HOMER3 promotes liver hepatocellular carcinoma cancer progression by -upregulating EZH2 and mediating miR-361/GPNMB axis.  |  Chen, L., et al. 2024. Pathol Res Pract. 254: 155150. PMID: 38266459
10. Identification of homer protein homolog 3 as a prognostic marker of colon adenocarcinoma.  |  Luo, M., et al. 2024. Heliyon. 10: e33344. PMID: 39035486

The preferred Homer antibody is Homer Antibody (D-3): sc-17842.