hnRNP Q Antibody (G-6): sc-271016
- hnRNP Q Antibody (G-6) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- raised against amino acids 373-432 mapping within an internal region of hnRNP Q of human origin
- recommended for detection of hnRNP Q of mouse, rat and human origin by WB, IP, IF and ELISA
- TransCruz reagent for ChIP application (sc-271016 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for hnRNP Q Antibody (G-6) for WB applications. These reagents are now offered in bundles with hnRNP Q Antibody (G-6) (see ordering information below).
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hnRNP Q Antibody (G-6) is a mouse monoclonal IgG2a antibody that detects heterogeneous nuclear ribonucleoprotein Q (hnRNP Q) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). hnRNP Q plays a pivotal role in RNA processing and is essential for efficient pre-mRNA splicing, a critical step in posttranscriptional regulation of gene expression. hnRNP Q is widely expressed across various tissues and is developmentally regulated, highlighting importance in cellular function and differentiation. hnRNP Q interacts with survival motor neuron protein (SMN), and disruptions in this interaction due to SMN function loss are linked to spinal muscular atrophy, a prevalent neurodegenerative disorder. hnRNP Q exhibits a unique expression pattern, being upregulated after midnight, which correlates with a decline in AANAT, the key enzyme involved in melatonin synthesis. This rhythmic regulation implicates hnRNP Q in the modulation of circadian rhythms, emphasizing significance in both gene expression and biological cycle maintenance.
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hnRNP Q Antibody (G-6) References:
- Rhythmic control of AANAT translation by hnRNP Q in circadian melatonin production. | Kim, TD., et al. 2007. Genes Dev. 21: 797-810. PMID: 17403780
- The RNA binding protein hnRNP Q modulates the utilization of exon 7 in the survival motor neuron 2 (SMN2) gene. | Chen, HH., et al. 2008. Mol Cell Biol. 28: 6929-38. PMID: 18794368
- hnRNP Q and PTB modulate the circadian oscillation of mouse Rev-erb alpha via IRES-mediated translation. | Kim, DY., et al. 2010. Nucleic Acids Res. 38: 7068-78. PMID: 20576698
- hnRNP Q mediates a phase-dependent translation-coupled mRNA decay of mouse Period3. | Kim, DY., et al. 2011. Nucleic Acids Res. 39: 8901-14. PMID: 21785138
- Rhythmic interaction between Period1 mRNA and hnRNP Q leads to circadian time-dependent translation. | Lee, KH., et al. 2012. Mol Cell Biol. 32: 717-28. PMID: 22124155
- hnRNP Q regulates translation of p53 in normal and stress conditions. | Kim, DY., et al. 2013. Cell Death Differ. 20: 226-34. PMID: 22935615
- Control of translation and miRNA-dependent repression by a novel poly(A) binding protein, hnRNP-Q. | Svitkin, YV., et al. 2013. PLoS Biol. 11: e1001564. PMID: 23700384
- Identification of miR-494 direct targets involved in senescence of human diploid fibroblasts. | Comegna, M., et al. 2014. FASEB J. 28: 3720-33. PMID: 24823364
- The Arabidopsis hnRNP-Q Protein LIF2 and the PRC1 Subunit LHP1 Function in Concert to Regulate the Transcription of Stress-Responsive Genes. | Molitor, AM., et al. 2016. Plant Cell. 28: 2197-2211. PMID: 27495811
- Syncrip/hnRNP Q is required for activity-induced Msp300/Nesprin-1 expression and new synapse formation. | Titlow, J., et al. 2020. J Cell Biol. 219: PMID: 32040548
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
hnRNP Q Antibody (G-6) | sc-271016 | 200 µg/ml | $322.00 | |||
hnRNP Q Antibody (G-6): m-IgG Fc BP-HRP Bundle | sc-540189 | 200 µg Ab; 10 µg BP | $361.00 | |||
hnRNP Q Antibody (G-6): m-IgG2a BP-HRP Bundle | sc-546870 | 200 µg Ab; 10 µg BP | $361.00 | |||
hnRNP Q Antibody (G-6) X | sc-271016 X | 200 µg/0.1 ml | $322.00 |