HNF-4α Antibody (Q-15): sc-101059

HNF-4α Antibody (Q-15) is a mouse monoclonal IgG2a kappa light chain antibody raised against recombinant human HNF-4α, also known as Hepatocyte Nuclear Factor 4 Alpha or NR2A1, with reactivity to mouse, rat, and human proteins. Anti-HNF-4α antibody (Q-15) is suitable for applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). HNF-4α is a nuclear receptor transcription factor crucial for regulating genes involved in glucose, lipid, and amino acid metabolism, playing a vital role in liver development and function. HNF-4α is predominantly expressed in the liver, kidney, pancreas, intestine, testis, and colon, influencing the transcription of numerous hepatocyte-specific genes such as cytochrome P450 enzymes and alpha-1 antitrypsin. Mutations in HNF-4α are associated with maturity-onset diabetes of the young type 1 (MODY1), underscoring HNF-4α′s importance in maintaining glucose homeostasis. HNF-4α interacts with other hepatocyte nuclear factors like HNF-1 and HNF-3 to regulate gene expression during early embryonic development and organogenesis. By studying HNF-4α, researchers can gain insights into metabolic regulation, liver diseases, and developmental biology. HNF-4α monoclonal antibody (Q-15) provides a reliable tool for investigating the function and regulation of HNF-4α in various biological processes and disease states.

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-HNF-4α Antibody (Q-15) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-HNF-4α Antibody (Q-15) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

HNF-4α Antibody (Q-15) Specifications

Alternate Product Name: HNF4A

Product Clone Name: Q-15

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 324-424

Epitope Target: HNF-4α

Epitope Species: human

Product Reactivity/Detection: HNF-4α

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 50 µg IgG_2a kappa light chain in 0.5 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for HNF-4α Antibody (Q-15): N/A

The preferred HNF-4α antibody is HNF-4α Antibody (H-1): sc-374229.