HMW-Guanylin Antibody (MAK-L-G-11): sc-59559

HMW-Guanylin Antibody (MAK-L-G-11) is a mouse monoclonal IgG1 antibody that detects HMW-Guanylin of human origin by enzyme-linked immunosorbent assay (ELISA). Anti-HMW-Guanylin antibody (MAK-L-G-11) is available as a non-conjugated format. HMW-Guanylin plays a crucial role in regulating intestinal fluid secretion, which is vital for maintaining proper digestion and nutrient absorption. HMW-Guanylin is primarily synthesized in the intestinal mucosa and secreted in response to food intake, where HMW-Guanylin activates membrane-bound guanylate cyclase, leading to increased levels of cyclic guanosine monophosphate (cGMP). The elevation of cGMP levels promotes fluid secretion into the intestinal lumen, facilitating the movement of digested food and electrolytes. HMW-Guanylin is also involved in acid neutralization, further underscoring its importance in gastrointestinal health. HMW-Guanylin is processed from a prohormone of 115 amino acids to its active form of 94 amino acids, which circulates in the bloodstream and exerts physiological effects. Using HMW-Guanylin monoclonal antibody (MAK-L-G-11) in your research can provide valuable insights into the regulatory mechanisms of intestinal function and potential implications for gastrointestinal disorders.

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HMW-Guanylin Antibody (MAK-L-G-11) References:

1. Guanylin peptides: renal actions mediated by cyclic GMP.  |  Forte, LR., et al. 2000. Am J Physiol Renal Physiol. 278: F180-91. PMID: 10662722
2. Human guanylin: cDNA isolation, structure, and activity.  |  Wiegand, RC., et al. 1992. FEBS Lett. 311: 150-4. PMID: 1327879
3. Guanylin: an endogenous activator of intestinal guanylate cyclase.  |  Currie, MG., et al. 1992. Proc Natl Acad Sci U S A. 89: 947-51. PMID: 1346555
4. Rat guanylin cDNA: characterization of the precursor of an endogenous activator of intestinal guanylate cyclase.  |  Wiegand, RC., et al. 1992. Biochem Biophys Res Commun. 185: 812-7. PMID: 1378267
5. Cloning and expression of guanylin. Its existence in various mammalian tissues.  |  Schulz, S., et al. 1992. J Biol Chem. 267: 16019-21. PMID: 1379587
6. Precursor structure, expression, and tissue distribution of human guanylin.  |  de Sauvage, FJ., et al. 1992. Proc Natl Acad Sci U S A. 89: 9089-93. PMID: 1409606
7. Analysis of the human guanylin gene and the processing and cellular localization of the peptide.  |  Hill, O., et al. 1995. Proc Natl Acad Sci U S A. 92: 2046-50. PMID: 7892222
8. Determination of the solution structure of the peptide hormone guanylin: observation of a novel form of topological stereoisomerism.  |  Skelton, NJ., et al. 1994. Biochemistry. 33: 13581-92. PMID: 7947768
9. The circulating bioactive form of human guanylin is a high molecular weight peptide (10.3 kDa).  |  Kuhn, M., et al. 1993. FEBS Lett. 318: 205-9. PMID: 8095028

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-HMW-Guanylin Antibody (MAK-L-G-11) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-HMW-Guanylin Antibody (MAK-L-G-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

HMW-Guanylin Antibody (MAK-L-G-11) Specifications

Alternate Product Name: HMW-Guanylin

Product Clone Name: MAK-L-G-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids: 78-94

Epitope Target: HMW-Guanylin

Epitope Species: human

Product Reactivity/Detection: HMW-Guanylin

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: ELISA

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for HMW-Guanylin Antibody (MAK-L-G-11): N/A