HMGI-C Antibody (2421C6a): sc-130024

HMGI-C Antibody (2421C6a) is a mouse monoclonal IgG1 kappa light chain antibody that detects HMGI-C protein of mouse, rat, and human origin by western blotting (WB) and immunoprecipitation (IP). Anti-HMGI-C antibody (2421C6a) is available as the non-conjugated format. HMGI-C protein, a member of the high mobility group (HMG) protein family, plays a crucial role in chromatin structure and function, acting as a non-histone component that influences DNA architecture. Specifically, HMGI-C binds to the minor groove of AT-rich DNA sequences, leading to significant alterations such as DNA bending and unwinding of the helix. This structural modification is vital as HMGI-C facilitates the binding of various transcription factors, including Oct-2 and members of the NFκB family, thereby enhancing transcriptional activation. Notably, HMGI-C is often associated with chromosomal translocations in tumors of mesenchymal origin, highlighting HMGI-C′s importance in cancer biology. Anti-HMGI-C antibody (2421C6a) effectively detects HMGI-C, making anti-HMGI-C antibody (2421C6a) an essential tool for researchers studying gene regulation, chromatin dynamics, and the molecular mechanisms underlying tumorigenesis.

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HMGI-C Antibody (2421C6a) References:

1. Onset of natural killer cell lymphomas in transgenic mice carrying a truncated HMGI-C gene by the chronic stimulation of the IL-2 and IL-15 pathway.  |  Baldassarre, G., et al. 2001. Proc Natl Acad Sci U S A. 98: 7970-5. PMID: 11427729
2. Structure of a gene coding for human HMG2 protein.  |  Shirakawa, H. and Yoshida, M. 1992. J Biol Chem. 267: 6641-5. PMID: 1551873
3. Structural features of the HMG chromosomal proteins and their genes.  |  Bustin, M., et al. 1990. Biochim Biophys Acta. 1049: 231-43. PMID: 2200521
4. A human placental cDNA clone that encodes nonhistone chromosomal protein HMG-1.  |  Wen, L., et al. 1989. Nucleic Acids Res. 17: 1197-214. PMID: 2922262
5. HMGI(Y) and Sp1 in addition to NF-kappa B regulate transcription of the MGSA/GRO alpha gene.  |  Wood, LD., et al. 1995. Nucleic Acids Res. 23: 4210-9. PMID: 7479086
6. Disruption of the architectural factor HMGI-C: DNA-binding AT hook motifs fused in lipomas to distinct transcriptional regulatory domains.  |  Ashar, HR., et al. 1995. Cell. 82: 57-65. PMID: 7606786
7. Structural basis for DNA bending by the architectural transcription factor LEF-1.  |  Love, JJ., et al. 1995. Nature. 376: 791-5. PMID: 7651541
8. Recurrent rearrangements in the high mobility group protein gene, HMGI-C, in benign mesenchymal tumours.  |  Schoenmakers, EF., et al. 1995. Nat Genet. 10: 436-44. PMID: 7670494
9. Changes in superhelicity are introduced into closed circular DNA by binding of high mobility group protein I/Y.  |  Nissen, MS. and Reeves, R. 1995. J Biol Chem. 270: 4355-60. PMID: 7876198
10. Reversal of intrinsic DNA bends in the IFN beta gene enhancer by transcription factors and the architectural protein HMG I(Y).  |  Falvo, JV., et al. 1995. Cell. 83: 1101-11. PMID: 8548798
11. Truncated and chimeric HMGI-C genes induce neoplastic transformation of NIH3T3 murine fibroblasts.  |  Fedele, M., et al. 1998. Oncogene. 17: 413-8. PMID: 9696033

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-HMGI-C Antibody (2421C6a) has 8 citations in a variety of scientific publications.

Primary antibodies like Anti-HMGI-C Antibody (2421C6a) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

HMGI-C Antibody (2421C6a) Specifications

Alternate Product Name: HMGA2

Product Clone Name: 2421C6a

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: HMGI-C

Epitope Species: human

Product Reactivity/Detection: HMGI-C

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 1.0% stabilizer protein

Research Citations: 8 citations in various scientific publications

Available Conjugates/Forms for HMGI-C Antibody (2421C6a): N/A