HLA-G Antibody (MEM-G/9): sc-51678
- HLA-G Antibody (MEM-G/9) is a mouse monoclonal IgG1, cited in 7 publications, provided at 100 µg/ml
- raised against recombinant HLA-G of human origin
- recommended for detection of native form of HLA-G on the cell surface as well as soluble HLA-G5 isoform in the β2-microglobulin associated form of human origin by WB, IP, IF and FCM
- See HLA-G (4H84): sc-21799 for HLA-G antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for HLA-G Antibody (MEM-G/9). This work is in progress.
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HLA-G Antibody (MEM-G/9) is a mouse monoclonal IgG1 antibody that detects HLA-G in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). HLA-G is a non-classical major histocompatibility complex (MHC) class I molecule that plays a crucial role in immune tolerance, particularly during pregnancy, by protecting the fetus from maternal immune rejection. HLA-G is primarily expressed in trophoblast cells of the placenta, where HLA-G helps to modulate the maternal immune response, ensuring a favorable environment for fetal development. The unique expression pattern of HLA-G, along with HLA-G′s ability to inhibit natural killer (NK) cell activity and T cell proliferation, underscores its importance in maintaining immune homeostasis during gestation. Additionally, HLA-G can undergo various post-translational modifications, such as glycosylation, which can influence HLA-G′s stability and interaction with immune cells, further highlighting its significance in immune regulation. Anti-HLA-G antibody (MEM-G/9) is an essential tool for researchers studying the intricate mechanisms of immune tolerance and the role of HLA-G in reproductive immunology.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
HLA-G Antibody (MEM-G/9) References:
- HLA-G in human reproduction: aspects of genetics, function and pregnancy complications. | Hviid, TV. 2006. Hum Reprod Update. 12: 209-32. PMID: 16280356
- Human leukocyte antigen-G and cancer immunoediting. | Urosevic, M. and Dummer, R. 2008. Cancer Res. 68: 627-30. PMID: 18245459
- Interaction between HLA-G and monocyte/macrophages in human pregnancy. | Shakhawat, A., et al. 2010. J Reprod Immunol. 85: 40-6. PMID: 20356631
- Expression of nonclassical molecule human leukocyte antigen-G in oral lesions. | Fregonezi, PA., et al. 2012. Am J Otolaryngol. 33: 193-8. PMID: 21035918
- Human leukocyte antigen-G in the male reproductive system and in seminal plasma. | Larsen, MH., et al. 2011. Mol Hum Reprod. 17: 727-38. PMID: 21813635
- Expression of human leukocyte antigen G is associated with prognosis in nasopharyngeal carcinoma. | Cai, MB., et al. 2012. Int J Biol Sci. 8: 891-900. PMID: 22745579
- Human leukocyte antigen-G (HLA-G) polymorphism and expression in breast cancer patients. | Jeong, S., et al. 2014. PLoS One. 9: e98284. PMID: 24870375
- Human Leukocyte Antigen-G Polymorphisms Association With Cancer Post-Heart Transplantation. | Lazarte, J., et al. 2016. Hum Immunol. 77: 805-11. PMID: 26776459
- The role of HLA-G in parasitic diseases. | Sabbagh, A., et al. 2018. HLA. 91: 255-270. PMID: 29368453
- Role of HLA-G in Viral Infections. | Jasinski-Bergner, S., et al. 2022. Front Immunol. 13: 826074. PMID: 35237271
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HLA-G Antibody (MEM-G/9) | sc-51678 | 100 µg/ml | $322.00 |