HLA-G Antibody (MEM-G/2): sc-51676
- HLA-G Antibody (MEM-G/2) is a mouse monoclonal IgG1, cited in 2 publications, provided at 100 µg/ml
- raised against recombinant HLA-G denatured heavy chain denatured heavy chain of human origin
- recommended for detection of free heavy chain of all HLA-G isoforms of human origin by WB, IP, IF and IHC(P)
- See HLA-G (4H84): sc-21799 for HLA-G antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for HLA-G Antibody (MEM-G/2). This work is in progress.
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SEE ALSO...
HLA-G Antibody (MEM-G/2) is a mouse monoclonal IgG1 antibody that detects HLA-G in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. HLA-G is a non-classical major histocompatibility complex (MHC) class I molecule that plays a crucial role in immune tolerance, particularly during pregnancy, by protecting the fetus from maternal immune rejection. HLA-G is primarily expressed in trophoblast cells of the placenta, where anti-HLA-G antibody (MEM-G/2) helps to modulate the maternal immune response, ensuring a favorable environment for fetal development. The unique expression pattern of HLA-G, along with its ability to inhibit natural killer (NK) cell activity and promote regulatory T cell development, underscores its importance in maintaining immune homeostasis. HLA-G′s structure, characterized by a shorter cytoplasmic tail compared to classical MHC molecules, allows HLA-G to engage in distinct signaling pathways that contribute to its immunomodulatory functions. HLA-G monoclonal antibody (MEM-G/2) is an essential tool for researchers studying the mechanisms of immune tolerance and the role of HLA-G in various pathological conditions, including cancer and autoimmune diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
HLA-G Antibody (MEM-G/2) References:
- Correlation of human leukocyte antigen-G (HLA-G) expression and disease progression in epithelial ovarian cancer. | Jung, YW., et al. 2009. Reprod Sci. 16: 1103-11. PMID: 19692629
- Human leukocyte antigen-G molecules are constitutively expressed by synovial fibroblasts and upmodulated in osteoarthritis. | Ongaro, A., et al. 2010. Hum Immunol. 71: 342-50. PMID: 20097242
- Identification of circulating nonclassic human leukocyte antigen G (HLA-G)-like molecules in exudates. | Gonzalez, A., et al. 2011. Clin Chem. 57: 1013-22. PMID: 21527645
- Human leukocyte antigen-G and regulatory T cells during specific immunotherapy for pollen allergy. | Sørensen, AE., et al. 2013. Int Arch Allergy Immunol. 162: 237-52. PMID: 24022071
- The human leukocyte antigen G molecule (HLA-G) expression in patients with nasal polyposis. | Avelino, MA., et al. 2014. Braz J Otorhinolaryngol. 80: 208-12. PMID: 25153104
- Interactions between HLA-G and HLA-E in Physiological and Pathological Conditions. | Morandi, F. and Pistoia, V. 2014. Front Immunol. 5: 394. PMID: 25202308
- HLA-G Orchestrates the Early Interaction of Human Trophoblasts with the Maternal Niche. | Gregori, S., et al. 2015. Front Immunol. 6: 128. PMID: 25870595
- Examining extended human leukocyte antigen-G and HLA-F haplotypes: the HLA-G UTR-4 haplotype is associated with shorter time to pregnancy in an infertility treatment setting when both female and male partners are carriers. | Nilsson, LL., et al. 2020. Fertil Steril. 114: 628-639. PMID: 32912613
- Roles of HLA-G/KIR2DL4 in Breast Cancer Immune Microenvironment. | Zheng, G., et al. 2022. Front Immunol. 13: 791975. PMID: 35185887
- HLA-G in asthma and its potential as an effective therapeutic agent. | Li, J., et al. 2023. Allergol Immunopathol (Madr). 51: 22-29. PMID: 36617818
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HLA-G Antibody (MEM-G/2) | sc-51676 | 100 µg/ml | $322.00 |