HLA-G Antibody (MEM-G/1): sc-51674
- HLA-G Antibody (MEM-G/1) is a mouse monoclonal IgG1, cited in 6 publications, provided at 100 µg/ml
- raised against recombinant HLA-G denatured heavy chain of human origin
- recommended for detection of denatured HLA-G heavy chain of human origin by WB, IP, IF and IHC(P)
- See HLA-G (4H84): sc-21799 for HLA-G antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for HLA-G Antibody (MEM-G/1). This work is in progress.
HLA-G Antibody (MEM-G/1) is a mouse monoclonal IgG1 antibody that detects HLA-G in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. HLA-G is a non-classical major histocompatibility complex (MHC) class I molecule that plays a crucial role in immune tolerance, particularly during pregnancy, by protecting the fetus from maternal immune rejection. HLA-G (MEM-G/1) antibody primarily recognizes HLA-G in trophoblast cells of the placenta, where HLA-G helps to modulate the maternal immune response, ensuring a favorable environment for fetal development. The unique expression pattern of HLA-G, along with its ability to inhibit natural killer (NK) cell activity and promote regulatory T cell development, underscores its importance in maintaining immune homeostasis. Additionally, HLA-G can undergo various post-translational modifications, such as glycosylation, which can influence its stability and interaction with immune cells, further emphasizing its role in immune regulation. Anti-HLA-G antibody (MEM-G/1) is an essential tool for researchers studying immune tolerance mechanisms and the implications of HLA-G in reproductive immunology and related disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
HLA-G Antibody (MEM-G/1) References:
- Human leukocyte antigen-G (HLA-G) as a marker for diagnosis, prognosis and tumor immune escape in human malignancies. | Yie, SM. and Hu, Z. 2011. Histol Histopathol. 26: 409-20. PMID: 21210353
- Human Leukocyte Antigen-G Within the Male Reproductive System: Implications for Reproduction. | Hviid, TV. 2015. Adv Exp Med Biol. 868: 171-90. PMID: 26178850
- Diagnostic significance of soluble human leukocyte antigen-G for gastric cancer. | Pan, YQ., et al. 2016. Hum Immunol. 77: 317-24. PMID: 26788811
- Soluble Human Leukocyte Antigen-G in the Bronchoalveolar Lavage of Lung Cancer Patients. | Montilla, D., et al. 2016. Arch Bronconeumol. 52: 420-4. PMID: 27004472
- Role of microRNAs on HLA-G expression in human tumors. | Seliger, B. 2016. Hum Immunol. 77: 760-3. PMID: 27142884
- Increased plasma soluble human leukocyte antigen-G in persistent wheezy infants. | Tahan, F., et al. 2017. Pediatr Int. 59: 530-533. PMID: 27880031
- Human leukocyte antigen-G 3' untranslated region polymorphisms are associated with asthma severity. | Alves, CC., et al. 2018. Mol Immunol. 101: 500-506. PMID: 30142579
- The Role of HLA-G in Human Papillomavirus Infections and Cervical Carcinogenesis. | Xu, HH., et al. 2020. Front Immunol. 11: 1349. PMID: 32670296
- Decreased serum human leukocyte antigen-G levels are associated with gestational diabetes mellitus. | Oztekin, O., et al. 2021. J Obstet Gynaecol Res. 47: 2329-2337. PMID: 33908106
- Detection of all isoforms of human leukocyte antigen G in maternal serum could be clinically applied for prediction of preeclampsa. | Zhang, JB., et al. 2022. Pregnancy Hypertens. 29: 7-13. PMID: 35660512
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HLA-G Antibody (MEM-G/1) | sc-51674 | 100 µg/ml | $322.00 |