HLA-G Antibody (9-1F10): sc-53825

HLA-G Antibody (9-1F10) is a mouse monoclonal IgG1 antibody that detects HLA-G in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). HLA-G is a non-classical major histocompatibility complex (MHC) class I molecule that plays a crucial role in immune tolerance, particularly during pregnancy, by protecting the fetus from maternal immune responses. HLA-G (9-1F10) antibody targets a protein primarily expressed in trophoblast cells of the placenta, where HLA-G helps to modulate the maternal immune system, preventing rejection of the semi-allogeneic fetus. The unique expression pattern of HLA-G, along with its ability to inhibit natural killer (NK) cell activity and promote regulatory T cell development, underscores its importance in maintaining a successful pregnancy and has implications in various pathological conditions, including cancer and autoimmune diseases. Anti-HLA-G antibody (9-1F10) is essential for researchers studying immune regulation and the mechanisms of tolerance, providing a valuable tool for understanding the complexities of immune interactions in both health and disease.

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HLA-G Antibody (9-1F10) References:

1. Lack of human leukocyte antigen-G expression in extravillous trophoblasts is associated with pre-eclampsia.  |  Goldman-Wohl, DS., et al. 2000. Mol Hum Reprod. 6: 88-95. PMID: 10611266
2. Biology and functions of human leukocyte antigen-G in health and sickness.  |  LeMaoult, J., et al. 2003. Tissue Antigens. 62: 273-84. PMID: 12974794
3. Expression of human leukocyte antigen G (HLA-G) correlates with poor prognosis in gastric carcinoma.  |  Yie, SM., et al. 2007. Ann Surg Oncol. 14: 2721-9. PMID: 17564748
4. Human leukocyte antigen-G (HLA-G) expression in cervical lesions: association with cancer progression, HPV 16/18 infection, and host immune response.  |  Dong, DD., et al. 2010. Reprod Sci. 17: 718-23. PMID: 20445010
5. Expression of human leukocyte antigen-G during normal placentation and in preeclamptic pregnancies.  |  Zhu, X., et al. 2012. Hypertens Pregnancy. 31: 252-60. PMID: 22150122
6. Human leukocyte antigen-G (HLA-G) expression in cervical cancer lesions is associated with disease progression.  |  Li, XJ., et al. 2012. Hum Immunol. 73: 946-9. PMID: 22820627
7. Human Leukocyte Antigen-G (HLA-G) Expression in Cancers: Roles in Immune Evasion, Metastasis and Target for Therapy.  |  Lin, A. and Yan, WH. 2015. Mol Med. 21: 782-791. PMID: 26322846
8. Roles of HLA-G in the Maternal-Fetal Immune Microenvironment.  |  Xu, X., et al. 2020. Front Immunol. 11: 592010. PMID: 33193435
9. An HLA-G/SPAG9/STAT3 axis promotes brain metastases.  |  Bassey-Archibong, BI., et al. 2023. Proc Natl Acad Sci U S A. 120: e2205247120. PMID: 36780531
10. Embryonic human leukocyte antigen-G expression: possible implications for human preimplantation development.  |  Jurisicova, A., et al. 1996. Fertil Steril. 65: 997-1002. PMID: 8612864

The preferred HLA-G antibody is HLA-G Antibody (4H84): sc-21799.