HLA-DRβ Antibody (HB10A): sc-73654

HLA-DRβ Antibody (HB10A) is a mouse monoclonal IgG2a antibody that detects HLA-DRβ in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. HLA-DRβ is a critical component of the major histocompatibility complex (MHC) class II molecules, which play a vital role in the immune response by presenting processed antigens to CD4+ T helper cells. Proper functioning of HLA-DRβ is essential for the activation of these T cells, which in turn orchestrate the adaptive immune response, making HLA-DRβ crucial for the body′s ability to fight infections and diseases. HLA-DRβ is primarily located on the surface of antigen-presenting cells, such as B cells and dendritic cells, where HLA-DRβ forms a heterodimer with the HLA-DRα chain. This localization allows for effective presentation of extracellular antigens to T cells, thereby initiating a robust immune response. Additionally, HLA-DRβ undergoes various post-translational modifications, including glycosylation, which can influence stability, expression levels, and interaction with other proteins, further underscoring HLA-DRβ′s importance in immune regulation. Anti-HLA-DRβ antibody (HB10A) serves as an invaluable tool for researchers studying immune responses, autoimmune diseases, and genetic factors influencing susceptibility to various conditions.

The preferred HLA-DRβ antibody is HLA-DRβ Antibody (DA2): sc-53314.