HLA-DR/DP Antibody (MEM-136): sc-51618
- HLA-DR/DP Antibody (MEM-136) is a mouse monoclonal IgG1, cited in 3 publications, provided at 100 µg/ml
- raised against PHA-activated human peripheral blood lymphocytes
- recommended for detection of common epitope on β-chain of HLA-DR and HLA-DP, the α/β dimer and the dissociated β-subunit of human origin by WB, IP and FCM
- available conjugated to phycoerythrin for IF, IHC(P) and FCM
- See HLA-DR (520B): sc-69673 for HLA-DR/DP antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for HLA-DR/DP Antibody (MEM-136). This work is in progress.
HLA-DR/DP Antibody (MEM-136) is a mouse monoclonal IgG1 antibody designed to recognize the β-chain of HLA-DR and HLA-DP proteins, also known as Human Leukocyte Antigen DR and DP or MHC class II DR and DP. These proteins are integral components of the major histocompatibility complex (MHC) class II molecules, which are predominantly located on the surface of antigen-presenting cells such as B lymphocytes, dendritic cells, and macrophages. This strategic cellular localization is crucial as it allows HLA-DR and HLA-DP to effectively present extracellular antigenic peptides to CD4+ T helper cells, thereby initiating and regulating adaptive immune responses essential for pathogen defense and immune surveillance. By targeting both the α/β dimer and the dissociated β-subunit of HLA-DR and HLA-DP, HLA-DR/DP (MEM-136) antibody provides comprehensive detection capabilities, making it invaluable for various applications including western blotting (WB) under non-reducing conditions, immunoprecipitation (IP), and flow cytometry (FCM). The precise localization of HLA-DR and HLA-DP on the cell surface is fundamental for their role in antigen presentation, influencing immune cell interactions and the overall immune response. Available in both conjugated and unconjugated forms, HLA-DR/DP (MEM-136) monoclonal antibody is an indispensable tool for immunologists and researchers aiming to elucidate the complexities of immune regulation and enhance the development of targeted immunotherapies and diagnostic strategies, ultimately contributing to improved patient outcomes and advancements in immunological research.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HLA-DR/DP Antibody (MEM-136) | sc-51618 | 100 µg/ml | $322.00 | |||
HLA-DR/DP Antibody (MEM-136) PE | sc-51618 PE | 100 tests in 2 ml | $349.00 |