HLA-DR Antibody (Bra22): sc-33718

HLA-DR Antibody (Bra22) is a mouse monoclonal IgG1 kappa light chain antibody designed to recognize and bind to HLA-DR and HLA-DP proteins, also known as human leukocyte antigen DR and DP or MHC class II DR and DP. These proteins are essential components of the major histocompatibility complex (MHC) class II molecules, which are composed of alpha and beta chains forming a heterodimer structure crucial for antigen presentation to CD4+ T helper cells. The structural integrity of HLA-DR is vital for its function in the immune system, as it facilitates the binding and presentation of peptide antigens, thereby initiating and regulating immune responses. Anti-HLA-DR antibody (Bra22) is raised against the Reh-6 non-T, non-B leukemia cell line and demonstrates broad species reactivity, effectively recognizing HLA-DR and HLA-DP from mouse, rat, and human origins. HLA-DR monoclonal antibody (Bra22) is versatile in its applications, suitable for western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM), and is available in both unconjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The precise structural targeting of HLA-DR by anti-HLA-DR antibody (Bra22) ensures reliable and specific detection, making this tool indispensable for researchers studying antigen presentation, immune cell interactions, and molecular mechanisms underlying immune-related diseases such as autoimmune disorders and cancers. By enabling detailed analysis of HLA-DR and HLA-DP structures and functions, HLA-DR (Bra22) antibody supports advancements in immunotherapy development, diagnostic strategies, and broader understanding of immune regulation, ultimately contributing to improved therapeutic outcomes and scientific insights.

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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-HLA-DR Antibody (Bra22) has 6 citations in a variety of scientific publications.

Primary antibodies like Anti-HLA-DR Antibody (Bra22) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

HLA-DR Antibody (Bra22) Specifications

Alternate Product Name: human leukocyte antigen (HLA) HLA-DR

Product Clone Name: Bra22

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: HLA-DR

Epitope Species: human

Product Reactivity/Detection: HLA-DR and HLA-DP

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), FCM

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 6 citations in various scientific publications

Available Conjugates/Forms for HLA-DR Antibody (Bra22): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred HLA-DR antibody is HLA-DR Antibody (L243): sc-18875.