HLA-DQ Antibody (TAL 4.1): sc-53312
- HLA-DQ Antibody (TAL 4.1) is a mouse monoclonal IgG2b κ, cited in 1 publications, provided at 200 µg/ml
- raised against WT46 cell line of human origin
- HLA-DQ Antibody (TAL 4.1) is recommended for detection of HLA-DQA1 and HLA-DQB1 of human origin by WB, IF and FCM
- Anti-HLA-DQ Antibody (TAL 4.1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG2b BP-HRP are the preferred secondary detection reagents for HLA-DQ Antibody (TAL 4.1) for WB applications. These reagents are now offered in bundles with HLA-DQ Antibody (TAL 4.1) (see ordering information below).
HLA-DQ Antibody (TAL 4.1) is a mouse monoclonal IgG2b kappa light chain antibody that detects HLA-DQA1 and HLA-DQB1 of human origin by western blotting (WB), immunofluorescence (IF), and flow cytometry (FCM). Anti-HLA-DQ antibody (TAL 4.1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. HLA-DQ plays a crucial role in the immune system as a major histocompatibility complex (MHC) class II molecule, which is essential for presenting processed antigens to CD4+ T helper cells. This interaction is vital for initiating and regulating immune responses, particularly in the context of autoimmune diseases and transplant rejection. HLA-DQ consists of two chains, α and β, that form a peptide-binding groove, allowing HLA-DQ to bind and present a diverse array of peptide antigens. HLA-DQ presentation of peptides is influenced by its conformation, which is modulated by other MHC molecules such as HLA-DM and HLA-DO. These interactions ensure that the immune system can effectively recognize and respond to pathogens while maintaining tolerance to self-antigens. Understanding HLA-DQ structural dynamics is important for developing therapeutic strategies in conditions like rheumatoid arthritis, where specific polymorphisms in HLA-DQ genes have been associated with disease susceptibility.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
HLA-DQ Antibody (TAL 4.1) References:
- HLA-DMA and HLA-DMB alleles in German patients with type 1 diabetes mellitus. | Siegmund, T., et al. 1999. Tissue Antigens. 54: 291-4. PMID: 10519369
- The association of HLA-DM genes with rheumatoid arthritis in Eastern France. | Toussirot, E., et al. 2000. Hum Immunol. 61: 303-8. PMID: 10689120
- Functional characterization of a lysosomal sorting motif in the cytoplasmic tail of HLA-DObeta. | Brunet, A., et al. 2000. J Biol Chem. 275: 37062-71. PMID: 10964920
- Determination of the HLA-DM interaction site on HLA-DR molecules. | Doebele, RC., et al. 2000. Immunity. 13: 517-27. PMID: 11070170
- Characterization of seven new monoclonal antibodies against human DR, DR + DP and DQ1 + DQ3 antigens. | Horejsí, V., et al. 1986. Tissue Antigens. 28: 288-97. PMID: 2435017
- B-cell lymphomas of high-grade malignancy frequently lack HLA-DR, -DP and -DQ antigens and associated invariant chain. | Momburg, F., et al. 1987. Int J Cancer. 40: 598-603. PMID: 3316049
- Human Ia molecules carrying DC1 determinants differ in both alpha- and beta-subunits from Ia molecules carrying DR determinants. | Corte, G., et al. 1981. Nature. 292: 357-60. PMID: 6166865
- Monoclonal antibodies to HLA determinants. | Bodmer, JG. and Bodmer, WF. 1984. Br Med Bull. 40: 267-75. PMID: 6205714
- A role for HLA-DO as a co-chaperone of HLA-DM in peptide loading of MHC class II molecules. | Kropshofer, H., et al. 1998. EMBO J. 17: 2971-81. PMID: 9606180
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HLA-DQ Antibody (TAL 4.1) | sc-53312 | 200 µg/ml | $322.00 | |||
HLA-DQ Antibody (TAL 4.1): m-IgG Fc BP-HRP Bundle | sc-525588 | 200 µg Ab; 10 µg BP | $361.00 | |||
HLA-DQ Antibody (TAL 4.1): m-IgG2b BP-HRP Bundle | sc-549590 | 200 µg Ab; 10 µg BP | $361.00 | |||
HLA-DQA1 Antibody (TAL 4.1) AC | sc-53312 AC | 500 µg/ml, 25% agarose | $424.00 | |||
HLA-DQA1 Antibody (TAL 4.1) HRP | sc-53312 HRP | 200 µg/ml | $322.00 | |||
HLA-DQA1 Antibody (TAL 4.1) FITC | sc-53312 FITC | 200 µg/ml | $336.00 | |||
HLA-DQA1 Antibody (TAL 4.1) PE | sc-53312 PE | 200 µg/ml | $349.00 | |||
HLA-DQA1 Antibody (TAL 4.1) Alexa Fluor® 488 | sc-53312 AF488 | 200 µg/ml | $364.00 | |||
HLA-DQ Antibody (TAL 4.1) Alexa Fluor® 546 | sc-53312 AF546 | 200 µg/ml | $364.00 | |||
HLA-DQA1 Antibody (TAL 4.1) Alexa Fluor® 594 | sc-53312 AF594 | 200 µg/ml | $364.00 | |||
HLA-DQA1 Antibody (TAL 4.1) Alexa Fluor® 647 | sc-53312 AF647 | 200 µg/ml | $364.00 | |||
HLA-DQA1 Antibody (TAL 4.1) Alexa Fluor® 680 | sc-53312 AF680 | 200 µg/ml | $364.00 | |||
HLA-DQA1 Antibody (TAL 4.1) Alexa Fluor® 790 | sc-53312 AF790 | 200 µg/ml | $364.00 |