HLA-DP Antibody (G-9): sc-390694
- HLA-DP Antibody (G-9) is a mouse monoclonal IgG2b κ HLA-DP antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 69-102 of HLA-DP of human origin
- HLA-DP Antibody (G-9) is recommended for detection of HLA-DP, HLA-DR, HLA-DRβ3, HLA-DRβ4, and HLA-DRβ5 of human origin, HLA-DQB1, H2-Eb1, and H2-Eb2 of mouse origin and the corresponding rat homologs by WB, IP, IF and ELISA; also reactive with additional species, including bovine
- Anti-HLA-DP Antibody (G-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for HLA-DP Antibody (G-9) for WB applications. These reagents are now offered in bundles with HLA-DP Antibody (G-9) (see ordering information below).
HLA-DP Antibody (G-9) is a mouse monoclonal IgG2b kappa light chain antibody designed to target the HLA-DP protein, a crucial component of the major histocompatibility complex (MHC) class II molecules. The HLA-DP protein, also known as Human Leukocyte Antigen DP, consists of alpha (DPA) and beta (DPB) chains that form a heterodimer essential for presenting antigenic peptides to CD4+ T helper cells, thereby playing a vital role in the immune response. Anti-HLA-DP antibody (G-9) specifically binds to an epitope mapped between amino acids 69-102 of the HLA-DP protein, ensuring high specificity and affinity. This structural recognition is important as it allows for precise detection and interaction studies involving HLA-DP, as well as related proteins such as HLA-DR, HLA-DQ, and their mouse and rat homologs. HLA-DP (G-9) antibody is versatile in its applications, effectively functioning in western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA) across multiple species, including humans, mice, rats, and bovines. Additionally, HLA-DP monoclonal antibody (G-9) is available in various conjugated forms, including horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® variants, facilitating diverse experimental needs. The detailed understanding of HLA-DP′s structure provided by anti-HLA-DP antibody (G-9) is essential for research in immunogenetics, autoimmune diseases, and transplant biology, where HLA-DP polymorphisms and interactions significantly impact disease susceptibility and immune compatibility. By offering robust and reliable performance, HLA-DP (G-9) monoclonal antibody supports advanced studies aimed at unraveling the complexities of immune regulation and enhancing therapeutic strategies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
HLA-DP Antibody (G-9) References:
- HLA-DMA and HLA-DMB alleles in German patients with type 1 diabetes mellitus. | Siegmund, T., et al. 1999. Tissue Antigens. 54: 291-4. PMID: 10519369
- The association of HLA-DM genes with rheumatoid arthritis in Eastern France. | Toussirot, E., et al. 2000. Hum Immunol. 61: 303-8. PMID: 10689120
- Functional HLA-DM on the surface of B cells and immature dendritic cells. | Arndt, SO., et al. 2000. EMBO J. 19: 1241-51. PMID: 10716924
- Functional characterization of a lysosomal sorting motif in the cytoplasmic tail of HLA-DObeta. | Brunet, A., et al. 2000. J Biol Chem. 275: 37062-71. PMID: 10964920
- The down-regulation of HLA-DM gene expression in rheumatoid arthritis is not related to their promoter polymorphism. | Louis-Plence, P., et al. 2000. J Immunol. 165: 4861-9. PMID: 11046010
- Determination of the HLA-DM interaction site on HLA-DR molecules. | Doebele, RC., et al. 2000. Immunity. 13: 517-27. PMID: 11070170
- Differential splenic migration of dendritic cells after immunologic unresponsiveness in rat hepatic allografts induced by pretransplant donor-specific transfusion. | Ohshiro, H., et al. 2001. J Surg Res. 101: 29-36. PMID: 11676551
- Monoclonal antibodies to HLA-DP-transfected mouse L cells. | Heyes, J., et al. 1986. Proc Natl Acad Sci U S A. 83: 3417-21. PMID: 3517859
- A role for HLA-DO as a co-chaperone of HLA-DM in peptide loading of MHC class II molecules. | Kropshofer, H., et al. 1998. EMBO J. 17: 2971-81. PMID: 9606180
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HLA-DP Antibody (G-9) | sc-390694 | 200 µg/ml | $322.00 | |||
HLA-DP Antibody (G-9): m-IgGκ BP-HRP Bundle | sc-523641 | 200 µg Ab, 40 µg BP | $361.00 | |||
HLA-DP Antibody (G-9): m-IgG2b BP-HRP Bundle | sc-549130 | 200 µg Ab; 10 µg BP | $361.00 | |||
HLA-DP Antibody (G-9) AC | sc-390694 AC | 500 µg/ml, 25% agarose | $424.00 | |||
HLA-DP Antibody (G-9) HRP | sc-390694 HRP | 200 µg/ml | $322.00 | |||
HLA-DP Antibody (G-9) FITC | sc-390694 FITC | 200 µg/ml | $336.00 | |||
HLA-DP Antibody (G-9) PE | sc-390694 PE | 200 µg/ml | $349.00 | |||
HLA-DP Antibody (G-9) Alexa Fluor® 488 | sc-390694 AF488 | 200 µg/ml | $364.00 | |||
HLA-DP Antibody (G-9) Alexa Fluor® 546 | sc-390694 AF546 | 200 µg/ml | $364.00 | |||
HLA-DP Antibody (G-9) Alexa Fluor® 594 | sc-390694 AF594 | 200 µg/ml | $364.00 | |||
HLA-DP Antibody (G-9) Alexa Fluor® 647 | sc-390694 AF647 | 200 µg/ml | $364.00 | |||
HLA-DP Antibody (G-9) Alexa Fluor® 680 | sc-390694 AF680 | 200 µg/ml | $364.00 | |||
HLA-DP Antibody (G-9) Alexa Fluor® 790 | sc-390694 AF790 | 200 µg/ml | $364.00 | |||
HLA-DP (G-9) Neutralizing Peptide | sc-390694 P | 100 µg/0.5 ml | $69.00 |