HLA-C Antibody (C-8): sc-166088
- HLA-C Antibody (C-8) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 91-123 within an internal region of HLA-C of human origin
- Anti-HLA-C Antibody (C-8) is recommended for detection of HLA-C of and human origin by WB, IP, IF and ELISA
- Anti-HLA-C Antibody (C-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for HLA-C Antibody (C-8) for WB applications. These reagents are now offered in bundles with HLA-C Antibody (C-8) (see ordering information below).
HLA-C Antibody (C-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects HLA-C of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). HLA-C Antibody (C-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. HLA-C plays a crucial role in the immune response as a member of the major histocompatibility complex (MHC) class I molecules, which are essential for presenting peptides derived from intracellular proteins to CD8+ cytotoxic T cells. Proper functioning of HLA-C is vital for the immune system′s ability to recognize and eliminate infected or malignant cells, thereby maintaining cellular integrity and preventing disease. Additionally, HLA-C interacts with various immune receptors, including killer immunoglobulin-like receptors (KIRs), which modulate the activity of natural killer (NK) cells. The polymorphic nature of HLA-C contributes to the diversity of immune responses among individuals, making HLA-C a significant factor in transplantation compatibility and susceptibility to autoimmune diseases. Understanding HLA-C interactions and functions is essential for advancing immunological research and therapeutic strategies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
HLA-C Antibody (C-8) References:
- HLA-DMA and HLA-DMB alleles in German patients with type 1 diabetes mellitus. | Siegmund, T., et al. 1999. Tissue Antigens. 54: 291-4. PMID: 10519369
- The association of HLA-DM genes with rheumatoid arthritis in Eastern France. | Toussirot, E., et al. 2000. Hum Immunol. 61: 303-8. PMID: 10689120
- Functional HLA-DM on the surface of B cells and immature dendritic cells. | Arndt, SO., et al. 2000. EMBO J. 19: 1241-51. PMID: 10716924
- Functional characterization of a lysosomal sorting motif in the cytoplasmic tail of HLA-DObeta. | Brunet, A., et al. 2000. J Biol Chem. 275: 37062-71. PMID: 10964920
- The down-regulation of HLA-DM gene expression in rheumatoid arthritis is not related to their promoter polymorphism. | Louis-Plence, P., et al. 2000. J Immunol. 165: 4861-9. PMID: 11046010
- Determination of the HLA-DM interaction site on HLA-DR molecules. | Doebele, RC., et al. 2000. Immunity. 13: 517-27. PMID: 11070170
- A role for HLA-DO as a co-chaperone of HLA-DM in peptide loading of MHC class II molecules. | Kropshofer, H., et al. 1998. EMBO J. 17: 2971-81. PMID: 9606180
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HLA-C Antibody (C-8) | sc-166088 | 200 µg/ml | $316.00 | |||
HLA-C Antibody (C-8): m-IgG Fc BP-HRP Bundle | sc-528904 | 200 µg Ab; 10 µg BP | $354.00 | |||
HLA-C Antibody (C-8): m-IgGκ BP-HRP Bundle | sc-521506 | 200 µg Ab, 40 µg BP | $354.00 | |||
HLA-C Antibody (C-8): m-IgG1 BP-HRP Bundle | sc-551252 | 200 µg Ab; 20 µg BP | $354.00 | |||
HLA-C Antibody (C-8) AC | sc-166088 AC | 500 µg/ml, 25% agarose | $416.00 | |||
HLA-C Antibody (C-8) HRP | sc-166088 HRP | 200 µg/ml | $316.00 | |||
HLA-C Antibody (C-8) FITC | sc-166088 FITC | 200 µg/ml | $330.00 | |||
HLA-C Antibody (C-8) PE | sc-166088 PE | 200 µg/ml | $343.00 | |||
HLA-C Antibody (C-8) Alexa Fluor® 488 | sc-166088 AF488 | 200 µg/ml | $357.00 | |||
HLA-C Antibody (C-8) Alexa Fluor® 546 | sc-166088 AF546 | 200 µg/ml | $357.00 | |||
HLA-C Antibody (C-8) Alexa Fluor® 594 | sc-166088 AF594 | 200 µg/ml | $357.00 | |||
HLA-C Antibody (C-8) Alexa Fluor® 647 | sc-166088 AF647 | 200 µg/ml | $357.00 | |||
HLA-C Antibody (C-8) Alexa Fluor® 680 | sc-166088 AF680 | 200 µg/ml | $357.00 | |||
HLA-C Antibody (C-8) Alexa Fluor® 790 | sc-166088 AF790 | 200 µg/ml | $357.00 | |||
HLA-C (C-8) Neutralizing Peptide | sc-166088 P | 100 µg/0.5 ml | $68.00 |