HLA-A/B/C Antibody (3F10): sc-65288

HLA-A/B/C Antibody (3F10) is a mouse monoclonal IgG2a antibody designed to recognize and bind to human leukocyte antigens HLA-A, HLA-B, and HLA-C, collectively known as MHC class I molecules. These proteins are critical components of the immune system, located on the surface of nearly all nucleated cells where they present endogenous peptide antigens to CD8+ cytotoxic T lymphocytes, facilitating immune surveillance and the elimination of infected or malignant cells. HLA-A/B/C molecules interact with several key proteins, including β2-microglobulin, which forms a stable heterodimer essential for their proper folding and surface expression, and T cell receptors (TCRs) on CD8+ T cells, which are vital for recognizing and responding to antigen-presenting cells. Additionally, HLA-A/B/C molecules engage with natural killer (NK) cell receptors such as killer immunoglobulin-like receptors (KIRs), regulating NK cell activity and maintaining immune homeostasis. Anti-HLA-A/B/C antibody (3F10) is raised against the HSB-2 T cell line of human origin, and demonstrates affinity for native HLA-A, HLA-B, and HLA-C proteins in their natural conformations. HLA-A/B/C (3F10) antibody is recommended for applications including immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM), making this tool indispensable for researchers investigating immune responses, autoimmunity, and transplant compatibility.

The preferred HLA class I antibody is HLA class I Antibody (HP-1F7): sc-69892.