HIV-2 gp39 Antibody (NYRHIV2gp39): sc-73301

HIV-2 gp39 Antibody (NYRHIV2gp39) is a mouse monoclonal IgG1 antibody that detects HIV-2 gp39 protein of HIV-2 origin by western blotting (WB) and enzyme-linked immunosorbent assay (ELISA). Anti-HIV-2 gp39 antibody (NYRHIV2gp39) is available as a non-conjugated format. HIV-2 gp39, an envelope glycoprotein specific to HIV-2, plays a crucial role in the virus′s ability to infect host cells by facilitating binding to the CD4 receptor on T cells. This interaction is vital for viral entry and subsequent replication, making HIV-2 gp39 essential for understanding HIV-2 pathogenesis and developing targeted therapies. Originally isolated from patients in West Africa, HIV-2 is the predominant form of HIV in that region and causes acquired immunodeficiency syndrome (AIDS). While HIV-1 and HIV-2 share similarities in genomic structure and clinical features, significant differences exist in their amino acid and nucleotide sequences, particularly in envelope glycoproteins, which can influence pathogenicity and transmission dynamics. Understanding unique properties of HIV-2 gp39 is important for advancing research and therapeutic strategies against this less common but clinically relevant form of HIV.

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HIV-2 gp39 Antibody (NYRHIV2gp39) References:

1. HIV-1 and HIV-2 infections and AIDS in West Africa.  |  De Cock, KM., et al. 1991. AIDS. 5 Suppl 1: S21-8. PMID: 1669921
2. Human immunodeficiency virus type 2 (HIV2).  |  Hughes, A. and Corrah, T. 1990. Blood Rev. 4: 158-64. PMID: 2245251
3. Oligosaccharide profiles of HIV-2 external envelope glycoprotein: dependence on host cells and virus isolates.  |  Liedtke, S., et al. 1994. Glycobiology. 4: 477-84. PMID: 7827409
4. HIV-2 transmembrane protein gp36 like HIV-1 gp41 binds to human lymphocytes and monocytes.  |  Chen, YH., et al. 1995. AIDS. 9: 1193-4. PMID: 8519457
5. Lessons from the second AIDS virus, HIV-2.  |  Marlink, R. 1996. AIDS. 10: 689-99. PMID: 8805859
6. T-helper reactivity to simian immunodeficiency virus gag synthetic peptides in human immunodeficiency virus type 2 infected individuals.  |  Pinto, LA., et al. 1995. J Med Virol. 47: 139-44. PMID: 8830117
7. Genetic variation in human immunodeficiency virus type 2: identification of a unique variant from human plasma.  |  Brennan, CA., et al. 1997. AIDS Res Hum Retroviruses. 13: 401-4. PMID: 9075481
8. Inhibition of HIV-1, HIV-2 and SIV envelope glycoprotein-mediated cell fusion by calmodulin.  |  Malvoisin, E. and Wild, F. 1997. Virus Res. 50: 119-27. PMID: 9282777
9. Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody.  |  Kwong, PD., et al. 1998. Nature. 393: 648-59. PMID: 9641677

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-HIV-2 gp39 Antibody (NYRHIV2gp39) has 1 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

HIV-2 gp39 Antibody (NYRHIV2gp39) Specifications

Alternate Product Name: HIV-2 gp39

Product Clone Name: NYRHIV2gp39

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: HIV-2 gp39

Epitope Species: HIV-2 gp39

Product Reactivity/Detection: HIV-2 gp39 envelope glycoprotein

Species Reactivity/Detection: HIV-2

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for HIV-2 gp39 Antibody (NYRHIV2gp39): N/A