HIV-2 gp36 Antibody (BDI411): sc-57831

HIV-2 gp36 Antibody (BDI411) is a mouse monoclonal IgG2a antibody that detects HIV-2 gp36 by western blotting (WB) and immunoprecipitation (IP). Anti-HIV-2 gp36 antibody (BDI411) is available as a non-conjugated format. HIV-2 gp36 plays a crucial role in the viral life cycle as a transmembrane protein located in the envelope of the virus, specifically associated with HIV-2. HIV-2 gp36 is essential for binding to cellular receptors, particularly putative proteins P45 and P62, which facilitate viral entry into host cells. Understanding HIV-2 gp36 interactions with these receptors is vital, as such insights can reveal mechanisms of viral infection and pathogenesis, potentially leading to targeted therapies and vaccines. HIV-2, originally isolated from patients in West Africa, is the dominant form of HIV in that region and can cause acquired immunodeficiency syndrome (AIDS). While HIV-2 shares similarities with HIV-1, including genome structure and clinical features, HIV-2 exhibits significant differences in amino acid and nucleotide sequences, particularly within envelope proteins, which may contribute to unique pathogenicity and longer incubation period.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

HIV-2 gp36 Antibody (BDI411) References:

1. HIV-2 transmembrane protein gp36 binds to the putative cellular receptor proteins P45 and P62.  |  Chen, YH., et al. 2000. Immunobiology. 201: 317-22. PMID: 10776788
2. Evaluation of HIV-1/HIV-2 immunoblots for detection of HIV-2 antibodies.  |  Walther, L., et al. 1995. Clin Diagn Virol. 4: 67-79. PMID: 15566829
3. HIV-1 and HIV-2 infections and AIDS in West Africa.  |  De Cock, KM., et al. 1991. AIDS. 5 Suppl 1: S21-8. PMID: 1669921
4. Specific synthetic peptides for detection of and discrimination between HIV-1 and HIV-2 infection.  |  Broliden, PA., et al. 1991. J Acquir Immune Defic Syndr (1988). 4: 952-8. PMID: 1679844
5. Performance characteristics of a novel immunoassay based on hybrid Ty virus-like particles (Ty-VLPs): rapid differentiation between HIV-1 and HIV-2 infection.  |  Gilmour, JE., et al. 1990. AIDS. 4: 967-73. PMID: 2124493
6. Human immunodeficiency virus type 2 (HIV2).  |  Hughes, A. and Corrah, T. 1990. Blood Rev. 4: 158-64. PMID: 2245251
7. [Evaluation of the immobilization of one HIV-2 gp36 peptide in nitrocellulose membrane].  |  Díaz Herrera, DF., et al. 2011. Rev Cubana Med Trop. 63: 135-40. PMID: 23437521
8. Insertion of a short human immunodeficiency virus (HIV)-2 gp36 sequence into an HIV-1 p24 recombinant protein results in a polypeptide with potent and TCRBV-restricted T cell triggering activity.  |  Imberti, L., et al. 1995. Eur J Immunol. 25: 218-25. PMID: 7843234
9. HIV-2 transmembrane protein gp36 like HIV-1 gp41 binds to human lymphocytes and monocytes.  |  Chen, YH., et al. 1995. AIDS. 9: 1193-4. PMID: 8519457
10. Lessons from the second AIDS virus, HIV-2.  |  Marlink, R. 1996. AIDS. 10: 689-99. PMID: 8805859
11. T-helper reactivity to simian immunodeficiency virus gag synthetic peptides in human immunodeficiency virus type 2 infected individuals.  |  Pinto, LA., et al. 1995. J Med Virol. 47: 139-44. PMID: 8830117
12. Genetic variation in human immunodeficiency virus type 2: identification of a unique variant from human plasma.  |  Brennan, CA., et al. 1997. AIDS Res Hum Retroviruses. 13: 401-4. PMID: 9075481

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-HIV-2 gp36 Antibody (BDI411) has 0 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

HIV-2 gp36 Antibody (BDI411) Specifications

Alternate Product Name: HIV-2 gp36

Product Clone Name: BDI411

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a

Amino Acids: 390-702

Epitope Target: HIV-2 gp36

Epitope Species: HIV-2 gp36

Product Reactivity/Detection: HIV-2 gp36 envelope glycoprotein

Species Reactivity/Detection: HIV-2

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 50 µg IgG_2a in 0.5 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for HIV-2 gp36 Antibody (BDI411): N/A