HIV-1 Tat Antibody (02-012): sc-65916
- HIV-1 Tat Antibody (02-012) is a mouse monoclonal IgG1, cited in 1 publications, provided at 100 µg/ml
- raised against amino acids 71-81 of Tat of HIV-1 origin
- recommended for detection of Tat of HIV-1 origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for HIV-1 Tat Antibody (02-012). This work is in progress.
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HIV-1 Tat Antibody (02-012) is a mouse monoclonal IgG1 antibody that detects HIV-1 Tat by western blotting (WB) and immunoprecipitation (IP). HIV-1 Tat is a pivotal viral protein that not only activates HIV gene expression but also plays a significant role in the pathogenesis of HIV-induced immunodeficiency. Anti-HIV-1 Tat antibody (02-012) recognizes a protein primarily located in the nucleus of infected cells, where HIV-1 Tat interacts with host transcriptional machinery to enhance viral replication. The nuclear localization of HIV-1 Tat is crucial because HIV-1 Tat exerts effects on the host cell′s gene expression, leading to continuous production of viral particles and contributing to chronic immune activation observed in HIV-infected individuals. Furthermore, nuclear HIV-1 Tat can disrupt normal cellular functions, promoting apoptosis and immune evasion, which are key factors in the progression to AIDS. HIV-1 Tat monoclonal antibody (02-012) serves as an essential tool for researchers studying the mechanisms of HIV pathogenesis and the development of potential therapeutic strategies.
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HIV-1 Tat Antibody (02-012) References:
- Inhibitors of HIV-1 Tat-mediated transactivation. | Richter, SN. and Palù, G. 2006. Curr Med Chem. 13: 1305-15. PMID: 16712471
- HIV-1 tat and rev upregulates osteoclast bone resorption. | Chew, N., et al. 2014. J Int AIDS Soc. 17: 19724. PMID: 25397470
- Caffeine Blocks HIV-1 Tat-Induced Amyloid Beta Production and Tau Phosphorylation. | Soliman, ML., et al. 2017. J Neuroimmune Pharmacol. 12: 163-170. PMID: 27629410
- Identification of HIV-1 Tat-Associated Proteins Contributing to HIV-1 Transcription and Latency. | Jean, MJ., et al. 2017. Viruses. 9: PMID: 28368303
- HIV-1 Tat potently stabilises Mdm2 and enhances viral replication. | Raja, R., et al. 2017. Biochem J. 474: 2449-2464. PMID: 28468838
- HIV-1 Tat regulation of dopamine transmission and microglial reactivity is brain region specific. | Miller, DR., et al. 2018. Glia. 66: 1915-1928. PMID: 29733459
- The HIV-1 Tat Protein Enhances Splicing at the Major Splice Donor Site. | Mueller, N., et al. 2018. J Virol. 92: PMID: 29743356
- Effects of HIV-1 Tat on oligodendrocyte viability are mediated by CaMKIIβ-GSK3β interactions. | Zou, S., et al. 2019. J Neurochem. 149: 98-110. PMID: 30674062
- HIV-1 Tat-Induced Astrocytic Extracellular Vesicle miR-7 Impairs Synaptic Architecture. | Hu, G., et al. 2020. J Neuroimmune Pharmacol. 15: 538-553. PMID: 31401755
- Structural Insights into the Mechanism of HIV-1 Tat Secretion from the Plasma Membrane. | Ghanam, RH., et al. 2023. J Mol Biol. 435: 167880. PMID: 36370804
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HIV-1 Tat Antibody (02-012) | sc-65916 | 100 µg/ml | $316.00 |