HIV-1 Tat Antibody (02-002): sc-65913
- HIV-1 Tat Antibody (02-002) is a mouse monoclonal IgG1, cited in 4 publications, provided at 100 µg/ml
- raised against amino acids 6-12 of Tat of HIV-1 origin
- recommended for detection of a Tat protein of HIV-1 origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for HIV-1 Tat Antibody (02-002). This work is in progress.
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HIV-1 Tat Antibody (02-002) is a mouse monoclonal IgG1 antibody that detects HIV-1 Tat by western blotting (WB) and immunoprecipitation (IP). HIV-1 Tat, also known as Tbp1, is a crucial viral protein that plays a significant role in activating HIV genes, contributing to HIV infection pathogenesis. Anti-HIV-1 Tat antibody (02-002) recognizes a protein primarily located in infected cells′ nuclei, where HIV-1 Tat interacts with host transcriptional machinery to enhance viral gene expression. Nuclear localization of HIV-1 Tat enables direct effects on viral replication and immune evasion at transcription sites, facilitating continuous viral particle production and contributing to chronic immune activation in HIV-infected individuals. HIV-1 Tat has been implicated in various AIDS-associated pathologies, including neurotoxicity and inflammation, as HIV-1 Tat can modulate apoptotic pathways and promote infected cell survival by upregulating anti-apoptotic factors. HIV-1 Tat monoclonal antibody (02-002) serves as an essential tool for researchers studying HIV pathogenesis mechanisms and developing therapeutic strategies targeting this critical viral protein.
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HIV-1 Tat Antibody (02-002) References:
- The cross-talk of HIV-1 Tat and methamphetamine in HIV-associated neurocognitive disorders. | Mediouni, S., et al. 2015. Front Microbiol. 6: 1164. PMID: 26557111
- HIV-1 Tat Primes and Activates Microglial NLRP3 Inflammasome-Mediated Neuroinflammation. | Chivero, ET., et al. 2017. J Neurosci. 37: 3599-3609. PMID: 28270571
- HIV-1 Tat alters neuronal intrinsic excitability. | Francesconi, W., et al. 2018. BMC Res Notes. 11: 275. PMID: 29728138
- HIV-1 Tat phosphorylation on Ser-16 residue modulates HIV-1 transcription. | Ivanov, A., et al. 2018. Retrovirology. 15: 39. PMID: 29792216
- HIV-1 TAT-mediated microglial activation: role of mitochondrial dysfunction and defective mitophagy. | Thangaraj, A., et al. 2018. Autophagy. 14: 1596-1619. PMID: 29966509
- HIV-1 Tat promotes astrocytic release of CCL2 through MMP/PAR-1 signaling. | Bozzelli, PL., et al. 2019. Glia. 67: 1719-1729. PMID: 31124192
- HIV-1 and HIV-1-Tat Induce Mitochondrial DNA Damage in Human Neurons. | Darbinian, N., et al. 2020. J HIV AIDS. 6: PMID: 33506104
- HIV-1 Tat endocytosis and retention in endolysosomes affects HIV-1 Tat-induced LTR transactivation in astrocytes. | Khan, N., et al. 2022. FASEB J. 36: e22184. PMID: 35113458
- HIV-1 Tat commandeers nuclear export of Rev-viral RNA complex by controlling hnRNPA2-mediated splicing. | Yandrapally, S., et al. 2023. J Virol. 97: e0104423. PMID: 37905837
- Role of HIV-1 Tat Protein Interactions with Host Receptors in HIV Infection and Pathogenesis. | Cafaro, A., et al. 2024. Int J Mol Sci. 25: PMID: 38338977
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HIV-1 Tat Antibody (02-002) | sc-65913 | 100 µg/ml | $316.00 |