HIV-1 RT Antibody (39/4.12.2): sc-57829

HIV-1 RT Antibody (39/4.12.2) is a mouse monoclonal IgG1 antibody that detects Pol RT (Reverse Transcriptase) of HIV-1 origin by western blotting (WB). Anti-HIV-1 RT antibody (39/4.12.2) is available in a non-conjugated form, specifically designed for HIV-1 RT detection applications. Reverse transcriptase plays a crucial role in retrovirus life cycles, transcribing viral single-stranded RNA genome into double-stranded DNA, which enables viral genome integration into host cell chromosomes. This process is vital for virus replication and infection establishment in human cells. Host cell tRNA serves as a primer, initiating complementary DNA strand synthesis. HIV-1 RT′s heterodimer structure coordinates enzymatic functions, making HIV-1 RT a target for antiretroviral therapies. Reverse transcriptase inhibitors, such as AZT, prevent viral RNA conversion into DNA, halting virus replication cycles.

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HIV-1 RT Antibody (39/4.12.2) References:

1. Human immunodeficiency virus reverse transcriptase and protease sequence database.  |  Rhee, SY., et al. 2003. Nucleic Acids Res. 31: 298-303. PMID: 12520007
2. Mechanism and fidelity of HIV reverse transcriptase.  |  Kati, WM., et al. 1992. J Biol Chem. 267: 25988-97. PMID: 1281479
3. Fidelity of HIV-1 reverse transcriptase.  |  Preston, BD., et al. 1988. Science. 242: 1168-71. PMID: 2460924
4. The accuracy of reverse transcriptase from HIV-1.  |  Roberts, JD., et al. 1988. Science. 242: 1171-3. PMID: 2460925
5. Use of the double-antibody method to separate antibody bound from free ligand in radioimmunoassay.  |  Midgley, AR. and Hepburn, MR. 1980. Methods Enzymol. 70: 266-74. PMID: 7421592
6. High resolution structures of HIV-1 RT from four RT-inhibitor complexes.  |  Ren, J., et al. 1995. Nat Struct Biol. 2: 293-302. PMID: 7540934
7. Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleoside inhibitors.  |  Esnouf, R., et al. 1995. Nat Struct Biol. 2: 303-8. PMID: 7540935
8. Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance.  |  Huang, H., et al. 1998. Science. 282: 1669-75. PMID: 9831551

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-HIV-1 RT Antibody (39/4.12.2) has 0 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

HIV-1 RT Antibody (39/4.12.2) Specifications

Alternate Product Name: HIV-1 RT

Product Clone Name: 39/4.12.2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target:

Epitope Species: HIV-1

Product Reactivity/Detection: Pol RT (Reverse Transcriptase)

Species Reactivity/Detection: HIV-1

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for HIV-1 RT Antibody (39/4.12.2): N/A