HIV-1 Protease Antibody (1696): sc-51614

HIV-1 Protease Antibody (1696) is a mouse monoclonal IgG1 antibody that detects HIV-1 Protease protein of HIV-1 origin by western blotting (WB). Anti-HIV-1 Protease antibody (1696) is available as a non-conjugated format, specifically designed to facilitate the study of this critical enzyme. HIV-1 Protease plays a vital role in the viral life cycle by hydrolyzing viral polyproteins into functional protein products, which are essential for the assembly and maturation of the virus. This enzymatic activity occurs during the budding process of the virion from the host cell, ensuring that the newly formed virus is infectious. HIV-1 Protease exists as a homodimer composed of two identical monomers, each containing 99 amino acids, arranged in a conformation that allows for an axis of symmetry in the active site. The secondary structure of each monomer includes one alpha-helix and two antiparallel beta sheets, which maintain the stability and functionality of the enzyme. Understanding the structure and function of HIV-1 Protease remains essential for developing targeted antiviral therapies, as inhibiting this protease can effectively disrupt viral replication.

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HIV-1 Protease Antibody (1696) References:

1. Inhibition of the HIV-1 and HIV-2 proteases by a monoclonal antibody.  |  Lescar, J., et al. 1999. Protein Sci. 8: 2686-96. PMID: 10631984
2. Diversification and specialization of HIV protease function during in vitro evolution.  |  O'Loughlin, TL., et al. 2006. Mol Biol Evol. 23: 764-72. PMID: 16423863
3. [Effects of various HIV protease inhibitors on function of rat insulinoma cells].  |  Zhou, JQ., et al. 2006. Zhejiang Da Xue Xue Bao Yi Xue Ban. 35: 251-4. PMID: 16764025
4. Simple determination of the HIV protease inhibitor atazanavir in human plasma by high-performance liquid chromatography with UV detection.  |  Loregian, A., et al. 2006. J Pharm Biomed Anal. 42: 500-5. PMID: 16765009
5. An efficient, stereoselective synthesis of the hydroxyethylene dipeptide isostere core for the HIV protease inhibitor A-792611.  |  Engstrom, K., et al. 2006. J Org Chem. 71: 5369-72. PMID: 16808529
6. Establishment of a new cell line inducibly expressing HIV-1 protease for performing safe and highly sensitive screening of HIV protease inhibitors.  |  Fuse, T., et al. 2006. Microbes Infect. 8: 1783-9. PMID: 16815068
7. Discovery of imidazolidine-2,4-dione-linked HIV protease inhibitors with activity against lopinavir-resistant mutant HIV.  |  Flosi, WJ., et al. 2006. Bioorg Med Chem. 14: 6695-712. PMID: 16828558
8. Unexpected novel binding mode of pyrrolidine-based aspartyl protease inhibitors: design, synthesis and crystal structure in complex with HIV protease.  |  Specker, E., et al. 2006. ChemMedChem. 1: 106-17. PMID: 16892342
9. A potent HIV protease inhibitor identified in an epimeric mixture by high-resolution protein crystallography.  |  Geremia, S., et al. 2006. ChemMedChem. 1: 186-8. PMID: 16892350

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-HIV-1 Protease Antibody (1696) has 2 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

HIV-1 Protease Antibody (1696) Specifications

Alternate Product Name: HIV-1 Protease

Product Clone Name: 1696

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: HIV-1 Protease

Epitope Species: HIV-1

Product Reactivity/Detection: the free N-terminus of mature Pol Protease

Species Reactivity/Detection: HIV-1

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for HIV-1 Protease Antibody (1696): N/A