Hippi Antibody (JA52): sc-130456
- Hippi Antibody (JA52) is a mouse monoclonal IgG2a κ provided at 100 µg/ml
- raised against recombinant Hippi of human origin
- recommended for detection of Hippi of human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Hippi Antibody (JA52). This work is in progress.
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SEE ALSO...
Hippi Antibody (JA52) is a mouse monoclonal IgG2a antibody that detects Hippi in human samples through western blotting (WB) and immunoprecipitation (IP) applications. Hippi, also known as Hip-1 protein interactor, plays a crucial role in the apoptotic pathways associated with neurodegenerative diseases, particularly Huntington′s disease. Hippi is primarily located in the cytoplasm, where anti-Hippi antibody (JA52) can detect interactions with the huntingtin protein (Htt) and other cellular components to regulate apoptosis. Hippi localization is significant because it allows for the formation of the Hippi-Hip-1 heterodimer, a pro-apoptotic complex that recruits procaspase-8, leading to the activation of caspase-8 and subsequent neuronal cell death. This process is particularly relevant in the context of Huntington′s disease, where the polyglutamine expansion of Htt disrupts normal interactions, resulting in increased levels of free Hippi. The human hippi gene, which encodes a 429 amino acid protein, is located on chromosome 3q13.13, highlighting genetic significance in neurodegenerative disorders. Hippi monoclonal antibody (JA52) serves as an essential tool for researchers studying the molecular mechanisms underlying neuronal apoptosis and the pathogenesis of Huntington′s disease.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Hippi Antibody (JA52) | sc-130456 | 100 µg/ml | $333.00 |