Hippi Antibody (D-6): sc-390120

Hippi Antibody (D-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects Hippi protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Hippi (D-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Hippi protein, also known as Hip-1 protein interactor, plays a crucial role in the regulation of programmed neuronal cell death, a process significantly implicated in neurodegenerative disorders such as Alzheimer′s and Huntington′s disease. Specifically, Hippi protein interacts with huntingtin (Htt), a protein whose polyglutamine expansions are associated with the pathogenesis of Huntington′s disease. The interaction between Hippi and Hip-1 forms a pro-apoptotic complex that recruits procaspase-8, leading to the activation of caspase-8 and subsequent neuronal apoptosis. This mechanism highlights Hippi′s importance in mediating cell death pathways that contribute to neurodegeneration. The human hippi gene is located on chromosome 3q13.13 and encodes a protein consisting of 429 amino acids, underscoring Hippi′s significance in cellular processes and potential as a therapeutic target in neurodegenerative diseases.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Hippi Antibody (D-6) References:

1. Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi.  |  Gervais, FG., et al. 2002. Nat Cell Biol. 4: 95-105. PMID: 11788820
2. Accomplices to neuronal death.  |  Mattson, MP. 2002. Nature. 415: 377-9. PMID: 11807533
3. Hip1 and Hippi participate in a novel cell death-signaling pathway.  |  Wanker, EE. 2002. Dev Cell. 2: 126-8. PMID: 11832235
4. Hip, hip, hippi!  |  Ferrier, V. 2002. Nat Cell Biol. 4: E30. PMID: 11835052

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Hippi Antibody (D-6) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Hippi Antibody (D-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Hippi Antibody (D-6) Specifications

Alternate Product Name: Hippi

Product Clone Name: D-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 198-429

Epitope Target: Hippi

Epitope Species: human

Product Reactivity/Detection: Hippi

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Hippi Antibody (D-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin