HIP1 Antibody (34): sc-135936
- HIP1 Antibody (34) is a mouse monoclonal IgG2a provided at 50 µg/0.5 ml
- raised against amino acids 365-480 of HIP1 of human origin
- recommended for detection of HIP1 of mouse, rat, human and canine origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for HIP1 Antibody (34). This work is in progress.
QUICK LINKS
HIP1 Antibody (34) is a mouse monoclonal IgG2a antibody that detects HIP1 in mouse, rat, human, and canine samples through western blotting (WB) and immunoprecipitation (IP) applications. HIP1, or huntingtin-interacting protein 1, plays a critical role in maintaining cellular integrity, particularly in the brain, where HIP1 is ubiquitously expressed at low levels across various regions. HIP1 is essential for vesicle trafficking, as HIP1 contains a C-terminal actin-binding domain, a central coiled-coil region, and an N-terminal ENTH domain, which together facilitate interaction with the cytoskeleton and membrane structures. The structural integrity of HIP1 is vital for the maintenance of normal vesicle size in vivo, and any disruption in HIP1 function can lead to compromised membrane-cytoskeletal integrity, particularly in the context of Huntington′s disease, where the interaction between HIP1 and huntingtin is inversely correlated with the length of the polyglutamine tract in huntingtin. The ability of HIP1 to bind specifically to the N-terminus of huntingtin underscores HIP1′s importance in neuronal health and function, making anti-HIP1 antibody (34) a valuable tool for researchers studying the molecular mechanisms underlying neurodegenerative diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
HIP1 Antibody (34) References:
- Transforming properties of the Huntingtin interacting protein 1/ platelet-derived growth factor beta receptor fusion protein. | Ross, TS. and Gilliland, DG. 1999. J Biol Chem. 274: 22328-36. PMID: 10428802
- Huntingtin interacting protein 1 induces apoptosis via a novel caspase-dependent death effector domain. | Hackam, AS., et al. 2000. J Biol Chem. 275: 41299-308. PMID: 11007801
- HIP12 is a non-proapoptotic member of a gene family including HIP1, an interacting protein with huntingtin. | Chopra, VS., et al. 2000. Mamm Genome. 11: 1006-15. PMID: 11063258
- Huntingtin-interacting protein-1-related protein of rat (rHIP1R) is localized in the postsynaptic regions. | Okano, A., et al. 2003. Brain Res. 967: 210-25. PMID: 12650982
- Huntingtin-interacting protein 1-mediated neuronal cell death occurs through intrinsic apoptotic pathways and mitochondrial alterations. | Choi, SA., et al. 2006. FEBS Lett. 580: 5275-82. PMID: 16979168
- Crystal structure at 2.8 A of the DLLRKN-containing coiled-coil domain of huntingtin-interacting protein 1 (HIP1) reveals a surface suitable for clathrin light chain binding. | Ybe, JA., et al. 2007. J Mol Biol. 367: 8-15. PMID: 17257618
- Aberrant Huntingtin interacting protein 1 in lymphoid malignancies. | Bradley, SV., et al. 2007. Cancer Res. 67: 8923-31. PMID: 17875735
- Use of a cryptic splice site for the expression of huntingtin interacting protein 1 in select normal and neoplastic tissues. | Graves, CW., et al. 2008. Cancer Res. 68: 1064-73. PMID: 18281481
- The microRNA-23b/-27b cluster suppresses prostate cancer metastasis via Huntingtin-interacting protein 1-related. | Rice, MA., et al. 2016. Oncogene. 35: 4752-61. PMID: 26898757
- Deficiency of the Endocytic Protein Hip1 Leads to Decreased Gdpd3 Expression, Low Phosphocholine, and Kypholordosis. | Wijayatunge, R., et al. 2018. Mol Cell Biol. 38: PMID: 30224518
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HIP1 Antibody (34) | sc-135936 | 50 µg/0.5 ml | $322.00 |