Hip Antibody (11A6): sc-136175
- Hip Antibody (11A6) is a mouse monoclonal IgG2a κ Hip antibody, cited in 1 publications, provided at 200 µg/ml
- raised against recombinant Hip of rat origin
- Hip Antibody (11A6) is recommended for detection of Hip of mouse, rat and human origin by WB and IP
- Anti-Hip Antibody (11A6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Hip Antibody (11A6) for WB applications. These reagents are now offered in bundles with Hip Antibody (11A6) (see ordering information below).
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Hip Antibody (11A6) is a mouse monoclonal IgG2a kappa light chain antibody that detects Hip protein of mouse, rat, and human origin by western blotting (WB) and immunoprecipitation (IP). Hip (11A6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Hip (11A6) monoclonal antibody recognizes a cochaperone that plays a crucial role in the Hsc 70/Hsp 40 reaction cycle, which is essential for protein folding and assembly within the cell. By binding to the ATPase domains of Hsc 70, Hip stabilizes the chaperone in an ADP-bound state, enhancing its affinity for substrate proteins. This interaction is vital for maintaining cellular protein homeostasis, as Hip prevents misfolding and aggregation, which can lead to cellular stress and disease. Hip′s ability to modulate the substrate specificity of the Hsc 70 complex underscores its importance in the intricate network of protein quality control mechanisms. With diverse applications and critical role in cellular function, anti-Hip antibody (11A6) serves as an invaluable tool for researchers studying protein interactions and chaperone-mediated processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Hip Antibody (11A6) References:
- Prevention of protein denaturation under heat stress by the chaperonin Hsp60. | Martin, J., et al. 1992. Science. 258: 995-8. PMID: 1359644
- Effects of low culture temperature on the induction of hsp70 mRNA and the accumulation of hsp70 and hsp105 in mouse FM3A cells. | Hatayama, T., et al. 1992. J Biochem. 111: 484-90. PMID: 1618738
- Hip, a novel cochaperone involved in the eukaryotic Hsc70/Hsp40 reaction cycle. | Höhfeld, J., et al. 1995. Cell. 83: 589-98. PMID: 7585962
- Protein-mediated protein maturation in eukaryotes. | Haas, IG. 1995. FEBS Lett. 369: 72-5. PMID: 7641888
- Can Hsp70 proteins act as force-generating motors? | Glick, BS. 1995. Cell. 80: 11-4. PMID: 7813006
- Cloning and subcellular localization of human mitochondrial hsp70. | Bhattacharyya, T., et al. 1995. J Biol Chem. 270: 1705-10. PMID: 7829505
- Autophosphorylation of grp94 (endoplasmin). | Csermely, P., et al. 1995. J Biol Chem. 270: 6381-8. PMID: 7890776
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Hip Antibody (11A6) | sc-136175 | 200 µg/ml | $322.00 | |||
Hip Antibody (11A6): m-IgG Fc BP-HRP Bundle | sc-528804 | 200 µg Ab; 10 µg BP | $361.00 | |||
Hip Antibody (11A6): m-IgGκ BP-HRP Bundle | sc-521336 | 200 µg Ab, 40 µg BP | $361.00 | |||
Hip Antibody (11A6): m-IgG2a BP-HRP Bundle | sc-547175 | 200 µg Ab; 10 µg BP | $361.00 | |||
Hip Antibody (11A6) AC | sc-136175 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Hip Antibody (11A6) HRP | sc-136175 HRP | 200 µg/ml | $322.00 | |||
Hip Antibody (11A6) FITC | sc-136175 FITC | 200 µg/ml | $336.00 | |||
Hip Antibody (11A6) PE | sc-136175 PE | 200 µg/ml | $349.00 | |||
Hip Antibody (11A6) Alexa Fluor® 488 | sc-136175 AF488 | 200 µg/ml | $364.00 | |||
Hip Antibody (11A6) Alexa Fluor® 546 | sc-136175 AF546 | 200 µg/ml | $364.00 | |||
Hip Antibody (11A6) Alexa Fluor® 594 | sc-136175 AF594 | 200 µg/ml | $364.00 | |||
Hip Antibody (11A6) Alexa Fluor® 647 | sc-136175 AF647 | 200 µg/ml | $364.00 | |||
Hip Antibody (11A6) Alexa Fluor® 680 | sc-136175 AF680 | 200 µg/ml | $364.00 | |||
Hip Antibody (11A6) Alexa Fluor® 790 | sc-136175 AF790 | 200 µg/ml | $364.00 |