hepatic OAT Antibody (F-2): sc-374310

Hepatic OAT Antibody (F-2) is a mouse monoclonal IgG2b antibody that detects hepatic OAT in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Hepatic OAT, a 439 amino acid protein encoded by the human gene OAT, plays a crucial role in the urea cycle by catalyzing the conversion of ornithine and α-ketoglutarate to glutamate and proline, which is vital for nitrogen metabolism and amino acid homeostasis. This protein is predominantly located in the mitochondrial matrix, where hepatic OAT functions as a homotetramer, highlighting its importance in cellular energy production and metabolic regulation. Deficiencies in hepatic OAT can lead to ornithinemia, a condition associated with gyrate atrophy of the choroid and retina, characterized by progressive vision loss. The clinical implications of hepatic OAT extend beyond enzymatic activity, as proper localization and function are essential for maintaining metabolic balance and preventing the accumulation of toxic metabolites. Anti-hepatic OAT antibody (F-2) is an invaluable tool for researchers studying metabolic disorders and mitochondrial function, providing insights into the underlying mechanisms of diseases associated with this critical enzyme.

The preferred OAT antibody is OAT Antibody (A-12): sc-374243.