Hep C cAg Antibody (C8-48): sc-81588

Hep C cAg Antibody (C8-48) is a mouse monoclonal IgG1 antibody that detects Hep C cAg protein of Hepatitis C Virus by western blotting (WB) and immunofluorescence (IF). Hep C cAg plays a crucial role in the life cycle of the hepatitis C virus, primarily functioning as a structural protein that forms the viral capsid, which is essential for the assembly and stability of the virus. The integrity of the capsid is vital for the virus′s ability to infect host cells, as it protects the viral RNA and facilitates the delivery of the genetic material into the cytoplasm of hepatocytes. Additionally, Hep C cAg protein is well conserved across various viral genotypes, which underscores its importance in the development of diagnostic tools and therapeutic strategies. The conservation of Hep C cAg protein also suggests potential as a target for vaccine development, as Hep C cAg could elicit a robust immune response across different strains of the virus. Hep C cAg (C8-48) monoclonal antibody serves as an invaluable tool for researchers studying hepatitis C virus biology, pathogenesis, and potential treatment options.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Hep C cAg Antibody (C8-48) References:

1. Subcellular localization of HCV core protein regulates its ability for p53 activation and p21 suppression.  |  Yamanaka, T., et al. 2002. Biochem Biophys Res Commun. 294: 528-34. PMID: 12056798
2. IFN-alpha antagonistic activity of HCV core protein involves induction of suppressor of cytokine signaling-3.  |  Bode, JG., et al. 2003. FASEB J. 17: 488-90. PMID: 12551851
3. Non-enveloped HCV core protein as constitutive antigen of cold-precipitable immune complexes in type II mixed cryoglobulinaemia.  |  Sansonno, D., et al. 2003. Clin Exp Immunol. 133: 275-82. PMID: 12869035
4. DNA methyltransferases 1 and 3b expression in Huh-7 cells expressing HCV core protein of different genotypes.  |  Benegiamo, G., et al. 2012. Dig Dis Sci. 57: 1598-603. PMID: 22526584
5. Recombinant HCV core protein and the secretion of associated cytokines (IL-6, TNF-α and IFN-γ) in immunized mice.  |  Torbati, E., et al. 2013. Pak J Biol Sci. 16: 2041-5. PMID: 24517026
6. Extracellular HCV-core protein induces an immature regulatory phenotype in NK cells: implications for outcome of acute infection.  |  Golden-Mason, L., et al. 2014. PLoS One. 9: e103219. PMID: 25076408
7. HCV core protein inhibits polarization and activity of both M1 and M2 macrophages through the TLR2 signaling pathway.  |  Zhang, Q., et al. 2016. Sci Rep. 6: 36160. PMID: 27786268
8. The unexpected function of a highly conserved YXXΦ motif in HCV core protein.  |  Karamichali, E., et al. 2017. Infect Genet Evol. 54: 251-262. PMID: 28687362
9. Mechanistic study of interaction between IL-22 and HCV core protein in the development of hepatocellular carcinoma among liver transplant recipients.  |  Resham, S., et al. 2020. Microb Pathog. 142: 104071. PMID: 32074496
10. HCV inhibits M2a, M2b and M2c macrophage polarization via HCV core protein engagement with Toll-like receptor 2.  |  Zhao, S., et al. 2022. Exp Ther Med. 24: 522. PMID: 35837038

The preferred Hep C cAg antibody is Hep C cAg Antibody (C7-50): sc-57800.