Hep B preS1 Antibody (KR127): sc-73587
- Hep B preS1 Antibody (KR127) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- raised against Hep B preS1
- recommended for detection of preS1 region of Hep B origin by WB, IP, IF and IHC(P)
- See Hep B preS1 (AP1): sc-57761 for Hep B preS1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Hep B preS1 Antibody (KR127) for WB and IHC(P) applications. These reagents are now offered in bundles with Hep B preS1 Antibody (KR127) (see ordering information below).
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Hep B preS1 Antibody (KR127) is a mouse monoclonal IgG2a antibody that detects Hep B preS1 in Hepatitis B virus by applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Hep B preS1 is a crucial envelope glycoprotein that plays a significant role in the viral life cycle, particularly in viral entry into host cells. Hep B preS1 is essential for viral attachment to and penetration of liver cells, which are the primary target for Hepatitis B infection. Understanding Hep B preS1 function is vital, as this protein not only facilitates viral entry but also influences immune response and development of chronic infection. Hep B preS1 presence in infected individuals′ serum can serve as a marker for viral replication and disease progression, making this protein an important target for both diagnostic and therapeutic strategies. Anti-Hep B preS1 antibody (KR127) serves as an invaluable tool for researchers studying Hepatitis B virus biology and developing vaccines and antiviral therapies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Hep B preS1 Antibody (KR127) References:
- Recombinant hepatitis B core antigen carrying preS1 epitopes induce immune response against chronic HBV infection. | Chen, X., et al. 2004. Vaccine. 22: 439-46. PMID: 14670326
- N-terminal myristoylation-dependent masking of neutralizing epitopes in the preS1 attachment site of hepatitis B virus. | Bremer, CM., et al. 2011. J Hepatol. 55: 29-37. PMID: 21145866
- Myristoylated PreS1-domain of the hepatitis B virus L-protein mediates specific binding to differentiated hepatocytes. | Meier, A., et al. 2013. Hepatology. 58: 31-42. PMID: 23213046
- Hepatitis B virus preS1-derived lipopeptide functionalized liposomes for targeting of hepatic cells. | Zhang, X., et al. 2014. Biomaterials. 35: 6130-41. PMID: 24797877
- The preS1 antigen of hepatitis B virus is highly immunogenic at the T cell level in man. | Ferrari, C., et al. 1989. J Clin Invest. 84: 1314-9. PMID: 2529268
- Hepatitis B virus PreS1 facilitates hepatocellular carcinoma development by promoting appearance and self-renewal of liver cancer stem cells. | Liu, Z., et al. 2017. Cancer Lett. 400: 149-160. PMID: 28455240
- Identification of Two Critical Neutralizing Epitopes in the Receptor Binding Domain of Hepatitis B Virus preS1. | Yato, K., et al. 2021. J Virol. 95: PMID: 33298539
- Lost Small Envelope Protein Expression from Naturally Occurring PreS1 Deletion Mutants of Hepatitis B Virus Is Often Accompanied by Increased HBx and Core Protein Expression as Well as Genome Replication. | Fu, S., et al. 2021. J Virol. 95: e0066021. PMID: 33910956
- PreS1 Containing HBc VLPs for the Development of a Combined Therapeutic/Prophylactic Hepatitis B Vaccine. | Dishlers, A., et al. 2023. Microorganisms. 11: PMID: 37110395
- Hepatitis B virus preS1 functions as a transcriptional activation domain. | Kim, HS., et al. 1997. J Gen Virol. 78 (Pt 5): 1083-6. PMID: 9152426
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Hep B preS1 Antibody (KR127) | sc-73587 | 200 µg/ml | $316.00 | |||
Hep B preS1 Antibody (KR127): m-IgG Fc BP-HRP Bundle | sc-537224 | 200 µg Ab; 10 µg BP | $354.00 | |||
Hep B preS1 Antibody (KR127): m-IgGκ BP-HRP Bundle | sc-534437 | 200 µg Ab; 40 µg BP | $354.00 | |||
Hep B preS1 Antibody (KR127): m-IgG2a BP-HRP Bundle | sc-547943 | 200 µg Ab; 10 µg BP | $354.00 |