Hep B preS1 Antibody (AP2): sc-57762
- Hep B preS1 Antibody (AP2) is a mouse monoclonal IgG2b κ, cited in 11 publications, provided at 200 µg/ml
- raised against Hep B preS1
- recommended for detection of preS1 region of Hep B origin by WB, IP, IF and IHC(P)
- See Hep B preS1 (AP1): sc-57761 for Hep B preS1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Hep B preS1 Antibody (AP2) for WB and IHC(P) applications. These reagents are now offered in bundles with Hep B preS1 Antibody (AP2) (see ordering information below).
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Hep B preS1 Antibody (AP2) is a mouse monoclonal IgG2b antibody that detects Hep B preS1 in Hepatitis B virus by applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Hep B preS1 is a crucial envelope glycoprotein that plays a significant role in the viral life cycle, particularly in viral entry into host cells. Hep B preS1 is essential for viral attachment to and penetration of hepatocytes, the primary cells of the liver, which is vital for establishing infection and subsequent replication. Hep B preS1 presence in the serum of infected individuals can indicate active viral replication and serves as a key target for diagnostic assays and therapeutic interventions. Anti-Hep B preS1 antibody (AP2) enables researchers to gain insights into the dynamics of Hepatitis B infection and immune response, ultimately aiding in the development of effective vaccines and treatments.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Hep B preS1 Antibody (AP2) References:
- Detection of anti-preS1 antibodies for recovery of hepatitis B patients by immunoassay. | Wei, J., et al. 2002. World J Gastroenterol. 8: 276-81. PMID: 11925607
- Expression of the PreS1 peptide of hepatitis B virus and preparation of its polyclonal antibody. | Chen, W., et al. 2011. Hybridoma (Larchmt). 30: 525-30. PMID: 22149277
- Targeted delivery of siRNA against hepatitis B virus by preS1 peptide molecular ligand. | Huang, W., et al. 2014. Hepatol Res. 44: 897-906. PMID: 23799901
- Hepatitis B virus preS1 deletion is related to viral replication increase and disease progression. | Lee, SA., et al. 2015. World J Gastroenterol. 21: 5039-48. PMID: 25945020
- Efficient Inhibition of Hepatitis B Virus Infection by a preS1-binding Peptide. | Ye, X., et al. 2016. Sci Rep. 6: 29391. PMID: 27384014
- N-Terminal PreS1 Sequence Regulates Efficient Infection of Cell-Culture-Generated Hepatitis B Virus. | Murayama, A., et al. 2021. Hepatology. 73: 520-532. PMID: 32446278
- TIMM29 interacts with hepatitis B virus preS1 to modulate the HBV life cycle. | Muriungi, NG. and Ueda, K. 2020. Microbiol Immunol. 64: 792-809. PMID: 32970362
- Serum PreS1 and HBsAg ratio reflects liver fibrosis and predicts the development of hepatocellular carcinoma in chronic hepatitis B patients. | Nishida, Y., et al. 2021. J Viral Hepat. 28: 1304-1311. PMID: 34105859
- 5' preS1 Mutations To Prevent Large Envelope Protein Expression from Hepatitis B Virus Genotype A or Genotype D Markedly Increase Polymerase-Envelope Fusion Protein. | Zhang, J., et al. 2022. J Virol. 96: e0172321. PMID: 35019714
- Impact of preS1 Evaluation in the Management of Chronic Hepatitis B Virus Infection. | Hayashi, Y., et al. 2024. Medicina (Kaunas). 60: PMID: 39202615
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Hep B preS1 Antibody (AP2) | sc-57762 | 200 µg/ml | $322.00 | |||
Hep B preS1 Antibody (AP2): m-IgGκ BP-HRP Bundle | sc-534335 | 200 µg Ab; 40 µg BP | $361.00 | |||
Hep B preS1 Antibody (AP2): m-IgG2b BP-HRP Bundle | sc-549247 | 200 µg Ab; 10 µg BP | $361.00 |