Hep B Pol Antibody (8D5): sc-81591

Hep B Pol Antibody (8D5) is a mouse monoclonal IgG1 antibody that detects Hepatitis B polymerase protein by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-Hepatitis B polymerase antibody (8D5) plays a crucial role in studying Hepatitis B polymerase, an enzyme essential for Hepatitis B virus replication. Hepatitis B polymerase (8D5) antibody enables detection of this protein primarily in the cytoplasm of infected cells, where Hepatitis B polymerase is encapsidated within the viral core along with pregenomic RNA. Hepatitis B polymerase localization is significant because reverse transcription begins in this compartment, allowing viral RNA conversion into DNA - critical for viral life cycle and host persistence. Understanding Hepatitis B polymerase cellular location provides insights into viral replication mechanisms and potential therapeutic interventions. Host cell chaperones such as HSP 70 and HSP 40 activate Hepatitis B polymerase, highlighting virus-host cellular environment interactions. Hepatitis B polymerase interactions with cellular factors and essential role in viral replication make this protein a key target for research and therapeutic strategies against Hepatitis B infection.

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Hep B Pol Antibody (8D5) References:

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2. A novel approach to characterise pathogen candidate genetic polymorphisms involved in clinical outcome.  |  Szmaragd, C., et al. 2006. Infect Genet Evol. 6: 38-45. PMID: 16376839
3. Clinical trial: a phase II, randomized study evaluating the safety, pharmacokinetics and anti-viral activity of clevudine for 12 weeks in patients with chronic hepatitis B.  |  Lim, SG., et al. 2008. Aliment Pharmacol Ther. 27: 1282-92. PMID: 18363895
4. Safety and efficacy of telbivudine for the treatment of chronic hepatitis B.  |  Osborn, MK. 2009. Ther Clin Risk Manag. 5: 789-98. PMID: 19851526
5. DNA polymerase inhibitors for treating hepatitis B: a safety evaluation.  |  Mak, LY., et al. 2016. Expert Opin Drug Saf. 15: 383-92. PMID: 26752687
6. Hepatitis B virus (HBV) genome detection and genotyping in virally suppressed patients using nested polymerase chain reaction-based Sanger sequencing.  |  Lau, KC., et al. 2019. Diagn Microbiol Infect Dis. 93: 318-324. PMID: 30471842
7. Betaine-assisted recombinase polymerase assay for rapid hepatitis B virus detection.  |  Yi, TT., et al. 2021. Biotechnol Appl Biochem. 68: 469-475. PMID: 32388885
8. Chronic Hepatitis B Treatment Strategies Using Polymerase Inhibitor-Based Combination Therapy.  |  Ohsaki, E., et al. 2021. Viruses. 13: PMID: 34578273
9. Dissecting Electronic-Structural Transitions in the Nitrogenase MoFe Protein P-Cluster during Reduction.  |  Chica, B., et al. 2022. J Am Chem Soc. 144: 5708-5712. PMID: 35315658
10. Significance of hepatitis B virus capsid dephosphorylation via polymerase.  |  Chang, CH. and Shih, C. 2024. J Biomed Sci. 31: 34. PMID: 38561844

The preferred Hep B Pol antibody is Hep B Pol Antibody (2C8): sc-81590.