Hep B cAg Antibody (10E11): sc-23947

Hep B cAg Antibody (10E11) is a mouse monoclonal IgG1 kappa light chain antibody that detects Hep B cAg in Hepatitis B and Woodchuck hepatitis through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Anti-Hep B cAg antibody (10E11) recognizes an epitope corresponding to amino acids 8-20 of the denatured core antigen of Hepatitis B virus, which is crucial for understanding viral life cycle and pathogenesis. The core antigen plays a vital role in viral capsid assembly, encapsulating the viral genome and ensuring stability during replication. This structural integrity is essential for viral infection of host cells and immune response evasion, making the core antigen a key target for diagnostic and therapeutic strategies. Hep B cAg monoclonal antibody (10E11) is available in non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatility for different experimental needs. The Hepatitis B virus, a member of the Hepadnavirus family, causes severe liver inflammation, jaundice, and potentially fatal outcomes, highlighting the importance of accurate antigen detection and monitoring in clinical settings.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Hep B cAg Antibody (10E11) References:

1. Recombinant hepatitis B core antigen carrying preS1 epitopes induce immune response against chronic HBV infection.  |  Chen, X., et al. 2004. Vaccine. 22: 439-46. PMID: 14670326
2. Antibody to hepatitis B core antigen and risk for hepatitis C-related hepatocellular carcinoma: a prospective study.  |  Ikeda, K., et al. 2007. Ann Intern Med. 146: 649-56. PMID: 17470833
3. Interaction of the hepatitis B core antigen and the innate immune system.  |  Lee, BO., et al. 2009. J Immunol. 182: 6670-81. PMID: 19454661
4. Hepatitis B virus (HBV) reactivation in rheumatic patients with hepatitis core antigen (HBV occult carriers) undergoing anti-tumor necrosis factor therapy.  |  Lee, YH., et al. 2013. Clin Exp Rheumatol. 31: 118-21. PMID: 23111095
5. Prevalence of antibody to Hepatitis B core antigen and Hepatitis B virus DNA in HBsAg negative healthy blood donors.  |  Karimi, G., et al. 2016. Virol J. 13: 36. PMID: 26944046
6. Hepatitis B virus core antigen mutations predict post-operative prognosis of patients with primary hepatocellular carcinoma.  |  Jia, J., et al. 2017. J Gen Virol. 98: 1399-1409. PMID: 28640739
7. Hepatitis B Core Antigen Impairs the Polarization While Promoting the Production of Inflammatory Cytokines of M2 Macrophages via the TLR2 Pathway.  |  Yi, H., et al. 2020. Front Immunol. 11: 535. PMID: 32292408
8. Hepatitis B core antigen modulates exosomal miR-135a to target vesicle-associated membrane protein 2 promoting chemoresistance in hepatocellular carcinoma.  |  Wei, XC., et al. 2021. World J Gastroenterol. 27: 8302-8322. PMID: 35068871
9. Role of Autophagy in the Ubiquitinated Hepatitis B Virus Core Antigen Enhancing Dendritic Cell Function.  |  Huang, R., et al. 2022. Viral Immunol. 35: 629-639. PMID: 36315216
10. GE11-antigen-loaded hepatitis B virus core antigen virus-like particles efficiently bind to TNBC tumor.  |  Zhang, L., et al. 2023. Front Oncol. 13: 1110751. PMID: 37020877

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Hep B cAg Antibody (10E11) has 20 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Hep B cAg Antibody (10E11) Specifications

Alternate Product Name: HBcAG

Product Clone Name: 10E11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: HBcAg

Epitope Species: Hepatitis B

Product Reactivity/Detection: an epitope corresponding to amino acids 8-20 of denatured core antigen

Species Reactivity/Detection: Hep B, Woodchuck hepatitis

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, FCM, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 20 citations in various scientific publications

Available Conjugates/Forms for Hep B cAg Antibody (10E11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Hep B cAg antibody is Hep B cAg Antibody (C1-5): sc-23945.