HEB Antibody (H-4): sc-365067
- HEB Antibody (H-4) is a mouse monoclonal IgM κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 652-683 within the C-terminus of HEB of human origin
- recommended for detection of HEB of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine and bovine
- TransCruz reagent for ChIP application (sc-365067 X, 200 µg/0.1 ml)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for HEB Antibody (H-4). This work is in progress.
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HEB Antibody (H-4) is a mouse monoclonal IgM antibody that detects HEB in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). HEB, a member of the basic helix-loop-helix (bHLH) transcription factor family, plays a crucial role in the regulation of gene expression during muscle cell differentiation. HEB (H-4) antibody targets proteins primarily located in the nucleus, where HEB forms heterodimers with other bHLH proteins, such as Myo D, to bind to E box elements in the promoter regions of muscle-specific genes. This interaction is vital for the activation of genes necessary for muscle development, highlighting HEB′s importance in myogenesis and muscle regeneration. Anti-HEB antibody (H-4) recognizes proteins that interact with various transcription factors to fine-tune target gene expression, making HEB a key player in the differentiation process. HEB monoclonal antibody (H-4) serves as an essential tool for researchers studying muscle biology and the molecular mechanisms underlying muscle cell differentiation and function.
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HEB Antibody (H-4) References:
- E2A/HEB and Id3 proteins control the sensitivity to glucocorticoid-induced apoptosis in thymocytes by regulating the SRG3 expression. | Ko, M., et al. 2004. J Biol Chem. 279: 21916-23. PMID: 15016815
- MyoD synergizes with the E-protein HEB beta to induce myogenic differentiation. | Parker, MH., et al. 2006. Mol Cell Biol. 26: 5771-83. PMID: 16847330
- E2A and HEB are required to block thymocyte proliferation prior to pre-TCR expression. | Wojciechowski, J., et al. 2007. J Immunol. 178: 5717-26. PMID: 17442955
- Developmental progression of fetal HEB(-/-) precursors to the pre-T-cell stage is restored by HEBAlt. | Braunstein, M. and Anderson, MK. 2010. Eur J Immunol. 40: 3173-82. PMID: 21061441
- The transcription factors E2A and HEB act in concert to induce the expression of FOXO1 in the common lymphoid progenitor. | Welinder, E., et al. 2011. Proc Natl Acad Sci U S A. 108: 17402-7. PMID: 21972416
- Med19 promotes breast cancer cell proliferation by regulating CBFA2T3/HEB expression. | Zhang, X., et al. 2017. Breast Cancer. 24: 433-441. PMID: 27572702
- Targeted Disruption of TCF12 Reveals HEB as Essential in Human Mesodermal Specification and Hematopoiesis. | Li, Y., et al. 2017. Stem Cell Reports. 9: 779-795. PMID: 28803914
- The Concerted Action of E2-2 and HEB Is Critical for Early Lymphoid Specification. | Bouderlique, T., et al. 2019. Front Immunol. 10: 455. PMID: 30936870
- Inhibitor of Differentiation 4 (ID4) represses mammary myoepithelial differentiation via inhibition of HEB. | Holliday, H., et al. 2021. iScience. 24: 102072. PMID: 33554073
- Helix-loop-helix (E2-5, HEB, TAL1 and Id1) protein interaction with the TCRalphadelta enhancers. | Bernard, M., et al. 1998. Int Immunol. 10: 1539-49. PMID: 9796921
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HEB Antibody (H-4) | sc-365067 | 200 µg/ml | $322.00 | |||
HEB (H-4) Neutralizing Peptide | sc-365067 P | 100 µg/0.5 ml | $69.00 | |||
HEB Antibody (H-4) X | sc-365067 X | 200 µg/0.1 ml | $322.00 |