Histone Deacetylase 9 (HDAC9) Antibody (B-1): sc-398003

HDAC9 Antibody (B-1) is a mouse monoclonal IgM antibody that detects HDAC9 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-HDAC9 antibody (B-1) is available as the non-conjugated form. HDAC9 protein plays a crucial role in gene expression regulation through function as a histone deacetylase, which removes acetyl groups from lysine residues on histones, leading to chromatin condensation and transcriptional repression. This process is vital for maintaining cellular homeostasis and regulating various biological processes, including cell differentiation and proliferation. HDAC9 is involved in muscle gene expression modulation and has been implicated in various diseases, including cancer and neurodegenerative disorders. HDAC9 exists in two alternatively spliced isoforms, HDAC9 and HDAC9a, with both retaining HDAC catalytic domain and deacetylase activity, yet differing in expression patterns and functional roles. HDAC9 is predominantly expressed in tissues such as brain, skeletal muscle, kidney, placenta, and pancreas, highlighting significance in both normal physiology and disease states.

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Histone Deacetylase 9 (HDAC9) Antibody (B-1) References:

1. Cloning and characterization of a histone deacetylase, HDAC9.  |  Zhou, X., et al. 2001. Proc Natl Acad Sci U S A. 98: 10572-7. PMID: 11535832
2. Downregulation of HDAC9 by the ketone metabolite β-hydroxybutyrate suppresses vascular calcification.  |  Lan, Z., et al. 2022. J Pathol. 258: 213-226. PMID: 35894849
3. HDAC9-mediated epithelial cell cycle arrest in G2/M contributes to kidney fibrosis in male mice.  |  Zhang, Y., et al. 2023. Nat Commun. 14: 3007. PMID: 37230975
4. Stroke by inducing HDAC9-dependent deacetylation of HIF-1 and Sp1, promotes TfR1 transcription and GPX4 reduction, thus determining ferroptotic neuronal death.  |  Sanguigno, L., et al. 2023. Int J Biol Sci. 19: 2695-2710. PMID: 37324938
5. HDAC9 Inhibition as a Novel Treatment for Stroke.  |  Markus, HS. 2023. Stroke. 54: 3182-3189. PMID: 37942644
6. Repressing HIF-1α-induced HDAC9 contributes to the synergistic effect of venetoclax and MENIN inhibitor in KMT2Ar AML.  |  Ling, Q., et al. 2023. Biomark Res. 11: 105. PMID: 38053201
7. Molecular mechanism and therapeutic potential of HDAC9 in intervertebral disc degeneration.  |  Lei, M., et al. 2023. Cell Mol Biol Lett. 28: 104. PMID: 38093179
8. Nucleosome structural changes due to acetylation.  |  Bauer, WR., et al. 1994. J Mol Biol. 236: 685-90. PMID: 8114086
9. A positive role for histone acetylation in transcription factor access to nucleosomal DNA.  |  Lee, DY., et al. 1993. Cell. 72: 73-84. PMID: 8422685
10. Transcriptional silencing in yeast is associated with reduced nucleosome acetylation.  |  Braunstein, M., et al. 1993. Genes Dev. 7: 592-604. PMID: 8458576
11. Nucleosomal DNA regulates the core-histone-binding subunit of the human Hat1 acetyltransferase.  |  Verreault, A., et al. 1998. Curr Biol. 8: 96-108. PMID: 9427644
12. Transcriptional activators direct histone acetyltransferase complexes to nucleosomes.  |  Utley, RT., et al. 1998. Nature. 394: 498-502. PMID: 9697775

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Histone Deacetylase 9 (HDAC9) Antibody (B-1) has 12 citations in a variety of scientific publications.

Primary antibodies like Anti-Histone Deacetylase 9 (HDAC9) Antibody (B-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Histone Deacetylase 9 (HDAC9) Antibody (B-1) Specifications

Alternate Product Name: HDAC9

Product Clone Name: B-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 12-39

Epitope Target: HDAC9

Epitope Species: human

Product Reactivity/Detection: HDAC9 isoforms 1-4

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 12 citations in various scientific publications

Available Conjugates/Forms for Histone Deacetylase 9 (HDAC9) Antibody (B-1): P: Blocking Peptide