Histone Deacetylase 7 (HDAC7) Antibody (A-7): sc-74563

HDAC7 Antibody (A-7) is a mouse monoclonal IgG2a kappa light chain antibody that detects HDAC7 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). HDAC7 (A-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. HDAC7 plays a crucial role in the regulation of gene expression through function as a histone deacetylase, which removes acetyl groups from lysine residues on histones, leading to chromatin condensation and transcriptional repression. This process is vital for maintaining cellular homeostasis and regulating developmental processes, as aberrant histone acetylation can result in uncontrolled gene expression and contribute to various diseases, including cancer. Additionally, HDAC7 interacts with several transcriptional co-repressors, such as mSin3A, which further underscores importance in the formation of transcriptional repression complexes. Anti-HDAC7 antibody (A-7) enables researchers to gain insights into the mechanisms of gene regulation and potential therapeutic targets for diseases associated with dysregulated histone modifications.

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Histone Deacetylase 7 (HDAC7) Antibody (A-7) References:

1. Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression.  |  Kao, HY., et al. 2000. Genes Dev. 14: 55-66. PMID: 10640276
2. Hdac7 promotes lung tumorigenesis by inhibiting Stat3 activation.  |  Lei, Y., et al. 2017. Mol Cancer. 16: 170. PMID: 29126425
3. HDAC7 promotes NSCLC proliferation and metastasis via stabilization by deubiquitinase USP10 and activation of β-catenin-FGF18 pathway.  |  Guo, K., et al. 2022. J Exp Clin Cancer Res. 41: 91. PMID: 35277183
4. The HDAC7-TET2 epigenetic axis is essential during early B lymphocyte development.  |  Azagra, A., et al. 2022. Nucleic Acids Res. 50: 8471-8490. PMID: 35904805
5. Melatonin inhibits ESCC tumor growth by mitigating the HDAC7/β-catenin/c-Myc positive feedback loop and suppressing the USP10-maintained HDAC7 protein stability.  |  Ma, ZQ., et al. 2022. Mil Med Res. 9: 54. PMID: 36163081
6. HDAC7 is an immunometabolic switch triaging danger signals for engagement of antimicrobial versus inflammatory responses in macrophages.  |  Das Gupta, K., et al. 2023. Proc Natl Acad Sci U S A. 120: e2212813120. PMID: 36649417
7. HDAC7/c-Myc signaling pathway promotes the proliferation and metastasis of choroidal melanoma cells.  |  Zhang, Y., et al. 2023. Cell Death Dis. 14: 38. PMID: 36653340
8. Nucleosome structural changes due to acetylation.  |  Bauer, WR., et al. 1994. J Mol Biol. 236: 685-90. PMID: 8114086
9. A positive role for histone acetylation in transcription factor access to nucleosomal DNA.  |  Lee, DY., et al. 1993. Cell. 72: 73-84. PMID: 8422685
10. Transcriptional silencing in yeast is associated with reduced nucleosome acetylation.  |  Braunstein, M., et al. 1993. Genes Dev. 7: 592-604. PMID: 8458576
11. Nucleosomal DNA regulates the core-histone-binding subunit of the human Hat1 acetyltransferase.  |  Verreault, A., et al. 1998. Curr Biol. 8: 96-108. PMID: 9427644
12. Transcriptional activators direct histone acetyltransferase complexes to nucleosomes.  |  Utley, RT., et al. 1998. Nature. 394: 498-502. PMID: 9697775

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Histone Deacetylase 7 (HDAC7) Antibody (A-7) has 25 citations in a variety of scientific publications.

Primary antibodies like Anti-Histone Deacetylase 7 (HDAC7) Antibody (A-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Histone Deacetylase 7 (HDAC7) Antibody (A-7) Specifications

Alternate Product Name: HDAC7

Product Clone Name: A-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 163-435

Epitope Target: HDAC7

Epitope Species: human

Product Reactivity/Detection: HDAC7

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 25 citations in various scientific publications

Available Conjugates/Forms for Histone Deacetylase 7 (HDAC7) Antibody (A-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent