HCR Antibody (E-4): sc-365889

HCR Antibody (E-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects HCR protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-HCR antibody (E-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. HCR protein, also known as coiled-coil α-helical rod protein 1 or putative gene 8 protein, consists of 782 amino acids and is encoded by the human gene CCHCR1. HCR protein plays a crucial role in regulating keratinocyte proliferation and differentiation, which is vital for maintaining skin integrity and function. HCR protein is predominantly located in the nucleus and is highly expressed in tissues such as the heart, liver, skeletal muscle, kidney, and pancreas, with lower expression levels in the lung and placenta. Notably, HCR protein is overexpressed in keratinocytes of psoriatic lesions, linking HCR to psoriasis, a chronic inflammatory skin condition affecting around 2% of the population. Psoriasis is characterized by red, scaly skin lesions, often found on the scalp, elbows, and knees, and can be associated with severe arthritis. The hyperproliferation of keratinocytes and the infiltration of inflammatory cells into the dermis and epidermis contribute to the formation of these lesions. While the usual onset of psoriasis occurs between the ages of 15 and 30, psoriasis can manifest at any age. The association of HCR with psoriasis appears to be due to linkage disequilibrium with the CW 0602 allele, although HCR is unlikely to be directly involved in the disease′s development.

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HCR Antibody (E-4) References:

1. A candidate gene for psoriasis near HLA-C, HCR (Pg8), is highly polymorphic with a disease-associated susceptibility allele.  |  Asumalahti, K., et al. 2000. Hum Mol Genet. 9: 1533-42. PMID: 10888604
2. The HCR gene on 6p21 is unlikely to be a psoriasis susceptibility gene.  |  O'Brien, KP., et al. 2001. J Invest Dermatol. 116: 750-4. PMID: 11348465
3. Coding haplotype analysis supports HCR as the putative susceptibility gene for psoriasis at the MHC PSORS1 locus.  |  Asumalahti, K., et al. 2002. Hum Mol Genet. 11: 589-97. PMID: 11875053
4. HCR, a candidate gene for psoriasis, is expressed differently in psoriasis and other hyperproliferative skin disorders and is downregulated by interferon-gamma in keratinocytes.  |  Suomela, S., et al. 2003. J Invest Dermatol. 121: 1360-4. PMID: 14675183
5. Genetic polymorphisms of the HCR gene and a genomic segment in close proximity to HLA-C are associated with patients with psoriasis in Taiwan.  |  Chang, YT., et al. 2004. Br J Dermatol. 150: 1104-11. PMID: 15214895
6. Mapping and identifying genes for asthma and psoriasis.  |  Kere, J. 2005. Philos Trans R Soc Lond B Biol Sci. 360: 1551-61. PMID: 16096103
7. Psoriasis vulgaris in Chinese individuals is associated with PSORS1C3 and CDSN genes.  |  Chang, YT., et al. 2006. Br J Dermatol. 155: 663-9. PMID: 16965413

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-HCR Antibody (E-4) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-HCR Antibody (E-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

HCR Antibody (E-4) Specifications

Alternate Product Name: HCR

Product Clone Name: E-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 361-660

Epitope Target: HCR

Epitope Species: human

Product Reactivity/Detection: HCR

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for HCR Antibody (E-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin