Hck Antibody (18): sc-136289
- Hck Antibody (18) is a mouse monoclonal IgG1 provided at 50 µg/0.5 ml
- raised against amino acids 2-300 of Hck of human origin
- recommended for detection of Hck of human origin by WB, IP and IF; also reactive with additional species, including canine
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Hck Antibody (18). This work is in progress.
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Hck Antibody (18) is a mouse monoclonal IgG1 antibody that detects Hck in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Hck, or human hemopoietic cell kinase, plays a crucial role in the signaling pathways of hematopoietic cells, particularly in granulocytes, where Hck is abundantly expressed. Human hemopoietic cell kinase is essential for regulating various cellular processes, including cell proliferation, differentiation, and migration, which are vital for immune responses and inflammation. Hck is localized primarily in the cytoplasm and can translocate to the cell membrane upon activation, highlighting Hck′s importance in modulating cellular signaling in response to external stimuli. Proper functioning of Hck is critical, as dysregulation can lead to hematological disorders and contribute to the development of certain cancers. Anti-Hck antibody (18) provides a reliable tool for researchers aiming to study the dynamics of Hck in various biological contexts, facilitating a deeper understanding of its role in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Hck Antibody (18) References:
- Identification of Hck inhibitors as hits for the development of antileukemia and anti-HIV agents. | Tintori, C., et al. 2013. ChemMedChem. 8: 1353-60. PMID: 23813855
- Involvement of the HCK and FGR src-family kinases in FCRL4-mediated immune regulation. | Liu, Y., et al. 2015. J Immunol. 194: 5851-60. PMID: 25972488
- Src family kinases, HCK and FGR, associate with local inflammation and tumour progression in colorectal cancer. | Roseweir, AK., et al. 2019. Cell Signal. 56: 15-22. PMID: 30684564
- Expression of the prosurvival kinase HCK requires PAX5 and mutated MYD88 signaling in MYD88-driven B-cell lymphomas. | Liu, X., et al. 2020. Blood Adv. 4: 141-153. PMID: 31935288
- Inhibition of the SRC Kinase HCK Impairs STAT3-Dependent Gastric Tumor Growth in Mice. | Poh, AR., et al. 2020. Cancer Immunol Res. 8: 428-435. PMID: 31992566
- HIV-1 Nef Induces Hck/Lyn-Dependent Expansion of Myeloid-Derived Suppressor Cells Associated with Elevated Interleukin-17/G-CSF Levels. | Priceputu, E., et al. 2021. J Virol. 95: e0047121. PMID: 34106001
- A new role for the SRC family kinase HCK as a driver of SYK activation in MYD88 mutated lymphomas. | Munshi, M., et al. 2022. Blood Adv. 6: 3332-3338. PMID: 35255496
- Kinase-deficient BTK mutants confer ibrutinib resistance through activation of the kinase HCK. | Dhami, K., et al. 2022. Sci Signal. 15: eabg5216. PMID: 35639855
- An SH3-binding allosteric modulator stabilizes the global conformation of the AML-associated Src-family kinase, Hck. | Selzer, AM., et al. 2025. J Biol Chem. 301: 108088. PMID: 39675702
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Hck Antibody (18) | sc-136289 | 50 µg/0.5 ml | $316.00 |